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Addition of molecular methods to mutation studies with Drosophila melanogaster.

Publication ,  Journal Article
Lee, WR
Published in: Environ Mol Mutagen
1989

For 80 years, Drosophila melanogaster has been used as a major tool in analyzing Mendelian genetics. By using chromosome inversions that suppress crossing over, geneticists have developed a large number of stocks for mutation analysis. These stocks permit numerous tests for specific locus mutations, lethals at multiple loci on any chromosome, chromosome exchanges, insertions, and deletions. The entire genome can be manipulated for a degree of genetic control not found in other germ-line systems. Recombinant DNA techniques now permit analysis of mutations to the nucleotide level. By combining classical genetic analysis with recombinant DNA techniques, it is possible to analyze mutations that range from chromosome aberrations and multilocus deficiencies to single nucleotide transitions.

Duke Scholars

Published In

Environ Mol Mutagen

DOI

ISSN

0893-6692

Publication Date

1989

Volume

14 Suppl 16

Start / End Page

99 / 104

Location

United States

Related Subject Headings

  • Toxicology
  • Drosophila melanogaster
  • DNA, Recombinant
  • DNA Mutational Analysis
  • Base Sequence
  • Animals
  • 4206 Public health
  • 3206 Medical biotechnology
  • 3105 Genetics
  • 11 Medical and Health Sciences
 

Citation

APA
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ICMJE
MLA
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Lee, W. R. (1989). Addition of molecular methods to mutation studies with Drosophila melanogaster. Environ Mol Mutagen, 14 Suppl 16, 99–104. https://doi.org/10.1002/em.2850140618
Lee, W. R. “Addition of molecular methods to mutation studies with Drosophila melanogaster.Environ Mol Mutagen 14 Suppl 16 (1989): 99–104. https://doi.org/10.1002/em.2850140618.
Lee WR. Addition of molecular methods to mutation studies with Drosophila melanogaster. Environ Mol Mutagen. 1989;14 Suppl 16:99–104.
Lee, W. R. “Addition of molecular methods to mutation studies with Drosophila melanogaster.Environ Mol Mutagen, vol. 14 Suppl 16, 1989, pp. 99–104. Pubmed, doi:10.1002/em.2850140618.
Lee WR. Addition of molecular methods to mutation studies with Drosophila melanogaster. Environ Mol Mutagen. 1989;14 Suppl 16:99–104.
Journal cover image

Published In

Environ Mol Mutagen

DOI

ISSN

0893-6692

Publication Date

1989

Volume

14 Suppl 16

Start / End Page

99 / 104

Location

United States

Related Subject Headings

  • Toxicology
  • Drosophila melanogaster
  • DNA, Recombinant
  • DNA Mutational Analysis
  • Base Sequence
  • Animals
  • 4206 Public health
  • 3206 Medical biotechnology
  • 3105 Genetics
  • 11 Medical and Health Sciences