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Prevalence, diagnostic features, and response to trabeculectomy in exfoliation glaucoma.

Publication ,  Journal Article
Konstas, AG; Jay, JL; Marshall, GE; Lee, WR
Published in: Ophthalmology
May 1993

BACKGROUND: The "true" prevalence and clinical attributes of exfoliation glaucoma remain controversial. The authors studied these characteristics in glaucoma patients requiring trabeculectomy. METHODS: One hundred consecutive patients undergoing trabeculectomy for open-angle glaucoma were investigated by clinical examination (biomicroscopy and gonioscopy) and classified into three categories: exfoliation glaucoma, possible exfoliation glaucoma, and primary open-angle glaucoma (POAG). A definitive diagnosis of exfoliation glaucoma was provided by pathologic examination of iris tissue. RESULTS: All 22 patients with clinical evidence of exfoliation glaucoma and 4 of 18 patients with possible exfoliation glaucoma on clinical examination had ultrastructural evidence of exfoliation material. The prevalence of exfoliation glaucoma, therefore, was 26%. The clinical examination for the diagnosis of exfoliation glaucoma had an 85% sensitivity rate and a 100% specificity rate. In comparison with POAG, patients with exfoliation glaucoma had higher untreated intraocular pressure (IOP), higher IOP with medical therapy, and shorter duration of medical therapy. They were more often operated on for unacceptably high IOP. Exfoliation glaucoma patients exhibited significantly lower IOP after surgery. CONCLUSION: Exfoliation glaucoma is common in patients requiring trabeculectomy for open-angle glaucoma. This condition differs from POAG by a poorer response to medical therapy and a better response to trabeculectomy.

Duke Scholars

Published In

Ophthalmology

DOI

ISSN

0161-6420

Publication Date

May 1993

Volume

100

Issue

5

Start / End Page

619 / 627

Location

United States

Related Subject Headings

  • Trabeculectomy
  • Prospective Studies
  • Prevalence
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Iris
  • Intraocular Pressure
  • Humans
  • Gonioscopy
 

Citation

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Chicago
ICMJE
MLA
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Konstas, A. G., Jay, J. L., Marshall, G. E., & Lee, W. R. (1993). Prevalence, diagnostic features, and response to trabeculectomy in exfoliation glaucoma. Ophthalmology, 100(5), 619–627. https://doi.org/10.1016/s0161-6420(93)31596-4
Konstas, A. G., J. L. Jay, G. E. Marshall, and W. R. Lee. “Prevalence, diagnostic features, and response to trabeculectomy in exfoliation glaucoma.Ophthalmology 100, no. 5 (May 1993): 619–27. https://doi.org/10.1016/s0161-6420(93)31596-4.
Konstas AG, Jay JL, Marshall GE, Lee WR. Prevalence, diagnostic features, and response to trabeculectomy in exfoliation glaucoma. Ophthalmology. 1993 May;100(5):619–27.
Konstas, A. G., et al. “Prevalence, diagnostic features, and response to trabeculectomy in exfoliation glaucoma.Ophthalmology, vol. 100, no. 5, May 1993, pp. 619–27. Pubmed, doi:10.1016/s0161-6420(93)31596-4.
Konstas AG, Jay JL, Marshall GE, Lee WR. Prevalence, diagnostic features, and response to trabeculectomy in exfoliation glaucoma. Ophthalmology. 1993 May;100(5):619–627.
Journal cover image

Published In

Ophthalmology

DOI

ISSN

0161-6420

Publication Date

May 1993

Volume

100

Issue

5

Start / End Page

619 / 627

Location

United States

Related Subject Headings

  • Trabeculectomy
  • Prospective Studies
  • Prevalence
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Iris
  • Intraocular Pressure
  • Humans
  • Gonioscopy