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Chronic effects of nitrendipine on renal hemodynamics and tubular transport.

Publication ,  Journal Article
Lupinacci, L; Palomino, C; Greenberg, A; Puschett, JB
Published in: Clin Pharmacol Ther
January 1988

The effects of nitrendipine (10 mg, during acute clearance experiments) given both acutely and after 2 weeks of administration were examined in normal and hypertensive subjects. At the initiation of therapy, nitrendipine caused an increase in glomerular filtration rate and effective renal plasma flow in the hypertensive, but not in the normal, group. Percentage excretion rates of sodium (%ENa) and phosphate (%EPi) and free water clearance (CW) increased in both groups at the initiation of therapy. After 2 weeks of nitrendipine therapy repeat acute clearance studies showed that the drug no longer increased glomerular filtration rate or effective renal plasma flow in hypertensive subjects, the increases in %ENa and CW persisted in normal subjects and trended upward in hypertensive subjects, and the increase in %EPi persisted in both normal and hypertensive individuals. We conclude that nitrendipine is not sodium retentive after chronic therapy and the acute increase in %ENa, %EPi, and CW after its initial administration suggests a proximal tubular effect.

Duke Scholars

Published In

Clin Pharmacol Ther

DOI

ISSN

0009-9236

Publication Date

January 1988

Volume

43

Issue

1

Start / End Page

6 / 15

Location

United States

Related Subject Headings

  • Time Factors
  • Renal Circulation
  • Pharmacology & Pharmacy
  • Nifedipine
  • Natriuresis
  • Male
  • Kidney Tubules, Proximal
  • Hypertension
  • Humans
  • Glomerular Filtration Rate
 

Citation

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Lupinacci, L., Palomino, C., Greenberg, A., & Puschett, J. B. (1988). Chronic effects of nitrendipine on renal hemodynamics and tubular transport. Clin Pharmacol Ther, 43(1), 6–15. https://doi.org/10.1038/clpt.1988.5
Lupinacci, L., C. Palomino, A. Greenberg, and J. B. Puschett. “Chronic effects of nitrendipine on renal hemodynamics and tubular transport.Clin Pharmacol Ther 43, no. 1 (January 1988): 6–15. https://doi.org/10.1038/clpt.1988.5.
Lupinacci L, Palomino C, Greenberg A, Puschett JB. Chronic effects of nitrendipine on renal hemodynamics and tubular transport. Clin Pharmacol Ther. 1988 Jan;43(1):6–15.
Lupinacci, L., et al. “Chronic effects of nitrendipine on renal hemodynamics and tubular transport.Clin Pharmacol Ther, vol. 43, no. 1, Jan. 1988, pp. 6–15. Pubmed, doi:10.1038/clpt.1988.5.
Lupinacci L, Palomino C, Greenberg A, Puschett JB. Chronic effects of nitrendipine on renal hemodynamics and tubular transport. Clin Pharmacol Ther. 1988 Jan;43(1):6–15.
Journal cover image

Published In

Clin Pharmacol Ther

DOI

ISSN

0009-9236

Publication Date

January 1988

Volume

43

Issue

1

Start / End Page

6 / 15

Location

United States

Related Subject Headings

  • Time Factors
  • Renal Circulation
  • Pharmacology & Pharmacy
  • Nifedipine
  • Natriuresis
  • Male
  • Kidney Tubules, Proximal
  • Hypertension
  • Humans
  • Glomerular Filtration Rate