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Hyperparathyroidism and 1,25-dihydroxyvitamin D deficiency in mild, moderate, and severe renal failure.

Publication ,  Journal Article
Pitts, TO; Piraino, BH; Mitro, R; Chen, TC; Segre, GV; Greenberg, A; Puschett, JB
Published in: J Clin Endocrinol Metab
November 1988

It has been postulated that hyperparathyroidism in chronic renal failure results from hypocalcemia, occurring, in part, from phosphate retention and/or deficient 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] synthesis. However, many studies have failed to demonstrate hyperphosphatemia or low 1,25-(OH)2D levels in patients with mild renal failure. We measured creatinine clearance (CCr), fractional excretion of phosphorus (FEP), and serum phosphorus, ionized calcium, and plasma N-terminal PTH, and 1,25-(OH)2D concentrations in 21 normal subjects and 51 patients with renal failure. Patients with mild renal failure (Ccr, greater than 40 mL/min.1.73 m2) had normal mean serum phosphorus and ionized calcium and decreased mean 1,25-(OH)2D levels compared with those in normal subjects. In patients with moderate renal failure (CCr, 20-40), the mean ionized calcium level was normal, plasma PTH levels and FEP were elevated, and the decrement in 1,25-(OH)2D was more pronounced. The mean ionized calcium level was decreased only in the group of patients with severe renal failure (CCr, less than 20). The 1,25-(OH)2D values correlated positively with CCr and negatively with the log of plasma PTH and serum phosphorus concentrations. Log of plasma PTH correlated negatively with CCr and positively with FEP. The ionized calcium concentration correlated very weakly with CCr and the log of the plasma PTH level. These data demonstrate the presence of hyperparathyroidism, normocalcemia, and 1,25-(OH)2D deficiency in renal failure and are consistent with a role for 1,25-(OH)2D in the suppression of parathyroid activity through as yet unidentified mechanisms.

Duke Scholars

Published In

J Clin Endocrinol Metab

DOI

ISSN

0021-972X

Publication Date

November 1988

Volume

67

Issue

5

Start / End Page

876 / 881

Location

United States

Related Subject Headings

  • Phosphorus
  • Parathyroid Hormone
  • Middle Aged
  • Metabolic Clearance Rate
  • Male
  • Kidney Failure, Chronic
  • Hyperparathyroidism
  • Humans
  • Female
  • Endocrinology & Metabolism
 

Citation

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MLA
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Pitts, T. O., Piraino, B. H., Mitro, R., Chen, T. C., Segre, G. V., Greenberg, A., & Puschett, J. B. (1988). Hyperparathyroidism and 1,25-dihydroxyvitamin D deficiency in mild, moderate, and severe renal failure. J Clin Endocrinol Metab, 67(5), 876–881. https://doi.org/10.1210/jcem-67-5-876
Pitts, T. O., B. H. Piraino, R. Mitro, T. C. Chen, G. V. Segre, A. Greenberg, and J. B. Puschett. “Hyperparathyroidism and 1,25-dihydroxyvitamin D deficiency in mild, moderate, and severe renal failure.J Clin Endocrinol Metab 67, no. 5 (November 1988): 876–81. https://doi.org/10.1210/jcem-67-5-876.
Pitts TO, Piraino BH, Mitro R, Chen TC, Segre GV, Greenberg A, et al. Hyperparathyroidism and 1,25-dihydroxyvitamin D deficiency in mild, moderate, and severe renal failure. J Clin Endocrinol Metab. 1988 Nov;67(5):876–81.
Pitts, T. O., et al. “Hyperparathyroidism and 1,25-dihydroxyvitamin D deficiency in mild, moderate, and severe renal failure.J Clin Endocrinol Metab, vol. 67, no. 5, Nov. 1988, pp. 876–81. Pubmed, doi:10.1210/jcem-67-5-876.
Pitts TO, Piraino BH, Mitro R, Chen TC, Segre GV, Greenberg A, Puschett JB. Hyperparathyroidism and 1,25-dihydroxyvitamin D deficiency in mild, moderate, and severe renal failure. J Clin Endocrinol Metab. 1988 Nov;67(5):876–881.
Journal cover image

Published In

J Clin Endocrinol Metab

DOI

ISSN

0021-972X

Publication Date

November 1988

Volume

67

Issue

5

Start / End Page

876 / 881

Location

United States

Related Subject Headings

  • Phosphorus
  • Parathyroid Hormone
  • Middle Aged
  • Metabolic Clearance Rate
  • Male
  • Kidney Failure, Chronic
  • Hyperparathyroidism
  • Humans
  • Female
  • Endocrinology & Metabolism