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Acute renal failure due to high-grade obstruction following therapy with epsilon-aminocaproic acid.

Publication ,  Journal Article
Pitts, TO; Spero, JA; Bontempo, FA; Greenberg, A
Published in: Am J Kidney Dis
December 1986

An 18-year-old man with mild factor VIII deficiency developed hematuria and, subsequently, acute renal failure due to high-grade urinary obstruction by clots during therapy with cryoprecipitate, epsilon-aminocaproic acid, and acetazolamide administered for ocular trauma. Discontinuation of therapy with the latter two agents and induction of a brisk diuresis with intravenous (IV) fluid therapy resulted in return of renal function concomitant with spontaneous clot passage. A review of previous literature suggests that hemophiliacs may be more susceptible than nonhemophiliacs to high-grade urinary obstruction due to clot formation when epsilon-aminocaproic acid is administered during episodes of hematuria. Acute flank pain, fever, and delayed dense nephrograms on IV pyelogram are characteristic of the syndrome and distinguish it from other forms of acute renal failure associated with epsilon-aminocaproic acid.

Duke Scholars

Published In

Am J Kidney Dis

DOI

ISSN

0272-6386

Publication Date

December 1986

Volume

8

Issue

6

Start / End Page

441 / 444

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Thrombosis
  • Male
  • Hyphema
  • Humans
  • Hemophilia A
  • Hematuria
  • Blood Coagulation
  • Aminocaproic Acid
  • Aminocaproates
 

Citation

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MLA
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Pitts, T. O., Spero, J. A., Bontempo, F. A., & Greenberg, A. (1986). Acute renal failure due to high-grade obstruction following therapy with epsilon-aminocaproic acid. Am J Kidney Dis, 8(6), 441–444. https://doi.org/10.1016/s0272-6386(86)80172-x
Pitts, T. O., J. A. Spero, F. A. Bontempo, and A. Greenberg. “Acute renal failure due to high-grade obstruction following therapy with epsilon-aminocaproic acid.Am J Kidney Dis 8, no. 6 (December 1986): 441–44. https://doi.org/10.1016/s0272-6386(86)80172-x.
Pitts TO, Spero JA, Bontempo FA, Greenberg A. Acute renal failure due to high-grade obstruction following therapy with epsilon-aminocaproic acid. Am J Kidney Dis. 1986 Dec;8(6):441–4.
Pitts, T. O., et al. “Acute renal failure due to high-grade obstruction following therapy with epsilon-aminocaproic acid.Am J Kidney Dis, vol. 8, no. 6, Dec. 1986, pp. 441–44. Pubmed, doi:10.1016/s0272-6386(86)80172-x.
Pitts TO, Spero JA, Bontempo FA, Greenberg A. Acute renal failure due to high-grade obstruction following therapy with epsilon-aminocaproic acid. Am J Kidney Dis. 1986 Dec;8(6):441–444.
Journal cover image

Published In

Am J Kidney Dis

DOI

ISSN

0272-6386

Publication Date

December 1986

Volume

8

Issue

6

Start / End Page

441 / 444

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Thrombosis
  • Male
  • Hyphema
  • Humans
  • Hemophilia A
  • Hematuria
  • Blood Coagulation
  • Aminocaproic Acid
  • Aminocaproates