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Prefrontal neuropsychological predictors of treatment remission in late-life depression.

Publication ,  Journal Article
Potter, GG; Kittinger, JD; Wagner, HR; Steffens, DC; Krishnan, KRR
Published in: Neuropsychopharmacology
December 2004

Recent studies suggest that neuropsychological measures involving the prefrontal cortex are associated with treatment remission in late-life depression. To further explore this issue, we studied the neuropsychological performance of 110 depressed individuals aged 60 years and over who are participating in an ongoing pharmacologic treatment study. Participants were clinically depressed at entry to the study as rated by the Montgomery-Asberg Depression Rating Scale (MADRS > or = 15), at which time they also completed a neuropsychological assessment that included measures of prefrontal/executive functions. A geriatric psychiatrist treating the participant using a standardized pharmacologic treatment algorithm evaluated the participant at baseline and 3-month follow-up, completing a MADRS at both visits. Using logistic discriminative procedures to predict depression remission at 3 months while controlling for age, gender, education, ethnicity, and baseline MADRS severity, we found that perseverative responses during verbal initiation tasks significantly predicted remission status (MADRS < 7). This finding is consistent with previous single-agent treatment studies suggesting a relationship between prefrontal neuropsychological function and treatment response in late-life depression. The current results, however, appear to differentiate verbal perseveration from verbal initiation as the cognitive process that is most associated with poor treatment response. By extension, we suggest that orbitofrontal prefrontal cortex may play a role in sustaining perseverative processing in geriatric depression.

Duke Scholars

Published In

Neuropsychopharmacology

DOI

ISSN

0893-133X

Publication Date

December 2004

Volume

29

Issue

12

Start / End Page

2266 / 2271

Location

England

Related Subject Headings

  • Treatment Outcome
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Prospective Studies
  • Problem Solving
  • Personality Inventory
  • Neuropsychological Tests
  • Middle Aged
  • Male
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Potter, G. G., Kittinger, J. D., Wagner, H. R., Steffens, D. C., & Krishnan, K. R. R. (2004). Prefrontal neuropsychological predictors of treatment remission in late-life depression. Neuropsychopharmacology, 29(12), 2266–2271. https://doi.org/10.1038/sj.npp.1300551
Potter, Guy G., Joshua D. Kittinger, H Ryan Wagner, David C. Steffens, and K Ranga Rama Krishnan. “Prefrontal neuropsychological predictors of treatment remission in late-life depression.Neuropsychopharmacology 29, no. 12 (December 2004): 2266–71. https://doi.org/10.1038/sj.npp.1300551.
Potter GG, Kittinger JD, Wagner HR, Steffens DC, Krishnan KRR. Prefrontal neuropsychological predictors of treatment remission in late-life depression. Neuropsychopharmacology. 2004 Dec;29(12):2266–71.
Potter, Guy G., et al. “Prefrontal neuropsychological predictors of treatment remission in late-life depression.Neuropsychopharmacology, vol. 29, no. 12, Dec. 2004, pp. 2266–71. Pubmed, doi:10.1038/sj.npp.1300551.
Potter GG, Kittinger JD, Wagner HR, Steffens DC, Krishnan KRR. Prefrontal neuropsychological predictors of treatment remission in late-life depression. Neuropsychopharmacology. 2004 Dec;29(12):2266–2271.
Journal cover image

Published In

Neuropsychopharmacology

DOI

ISSN

0893-133X

Publication Date

December 2004

Volume

29

Issue

12

Start / End Page

2266 / 2271

Location

England

Related Subject Headings

  • Treatment Outcome
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Prospective Studies
  • Problem Solving
  • Personality Inventory
  • Neuropsychological Tests
  • Middle Aged
  • Male
  • Humans