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Chronic levodopa or pergolide administration induces down-regulation of dopamine receptors in denervated striatum.

Publication ,  Journal Article
Reches, A; Wagner, HR; Jackson-Lewis, V; Yablonskaya-Alter, E; Fahn, S
Published in: Neurology
September 1984

Refractory response to dopamine (DA) agonists is a common problem in the treatment of Parkinson's disease. In rats with unilateral lesions of the substantia nigra, denervation induced significant increases in striatal 3(H)-spiperone binding sites ipsilateral to the lesion. Chronic treatment with levodopa or with pergolide mesylate significantly decreased the number of 3(H)-spiperone striatal binding sites. Agonist-induced decreases were approximately equivalent in intact and denervated striata and did not appear to be affected by lesions. These results suggest that the poor response to DA agonist in certain parkinsonian patients with chronic drug exposure may be mediated by drug-induced DA receptor down-regulation.

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Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

September 1984

Volume

34

Issue

9

Start / End Page

1208 / 1212

Location

United States

Related Subject Headings

  • Receptors, Dopamine
  • Rats, Inbred Strains
  • Rats
  • Pergolide
  • Parkinson Disease
  • Neurology & Neurosurgery
  • Male
  • Levodopa
  • Ergolines
  • Denervation
 

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Reches, A., Wagner, H. R., Jackson-Lewis, V., Yablonskaya-Alter, E., & Fahn, S. (1984). Chronic levodopa or pergolide administration induces down-regulation of dopamine receptors in denervated striatum. Neurology, 34(9), 1208–1212. https://doi.org/10.1212/wnl.34.9.1208
Reches, A., H. R. Wagner, V. Jackson-Lewis, E. Yablonskaya-Alter, and S. Fahn. “Chronic levodopa or pergolide administration induces down-regulation of dopamine receptors in denervated striatum.Neurology 34, no. 9 (September 1984): 1208–12. https://doi.org/10.1212/wnl.34.9.1208.
Reches A, Wagner HR, Jackson-Lewis V, Yablonskaya-Alter E, Fahn S. Chronic levodopa or pergolide administration induces down-regulation of dopamine receptors in denervated striatum. Neurology. 1984 Sep;34(9):1208–12.
Reches, A., et al. “Chronic levodopa or pergolide administration induces down-regulation of dopamine receptors in denervated striatum.Neurology, vol. 34, no. 9, Sept. 1984, pp. 1208–12. Pubmed, doi:10.1212/wnl.34.9.1208.
Reches A, Wagner HR, Jackson-Lewis V, Yablonskaya-Alter E, Fahn S. Chronic levodopa or pergolide administration induces down-regulation of dopamine receptors in denervated striatum. Neurology. 1984 Sep;34(9):1208–1212.

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

September 1984

Volume

34

Issue

9

Start / End Page

1208 / 1212

Location

United States

Related Subject Headings

  • Receptors, Dopamine
  • Rats, Inbred Strains
  • Rats
  • Pergolide
  • Parkinson Disease
  • Neurology & Neurosurgery
  • Male
  • Levodopa
  • Ergolines
  • Denervation