Chronic levodopa or pergolide administration induces down-regulation of dopamine receptors in denervated striatum.
Publication
, Journal Article
Reches, A; Wagner, HR; Jackson-Lewis, V; Yablonskaya-Alter, E; Fahn, S
Published in: Neurology
September 1984
Refractory response to dopamine (DA) agonists is a common problem in the treatment of Parkinson's disease. In rats with unilateral lesions of the substantia nigra, denervation induced significant increases in striatal 3(H)-spiperone binding sites ipsilateral to the lesion. Chronic treatment with levodopa or with pergolide mesylate significantly decreased the number of 3(H)-spiperone striatal binding sites. Agonist-induced decreases were approximately equivalent in intact and denervated striata and did not appear to be affected by lesions. These results suggest that the poor response to DA agonist in certain parkinsonian patients with chronic drug exposure may be mediated by drug-induced DA receptor down-regulation.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Neurology
DOI
ISSN
0028-3878
Publication Date
September 1984
Volume
34
Issue
9
Start / End Page
1208 / 1212
Location
United States
Related Subject Headings
- Receptors, Dopamine
- Rats, Inbred Strains
- Rats
- Pergolide
- Parkinson Disease
- Neurology & Neurosurgery
- Male
- Levodopa
- Ergolines
- Denervation
Citation
APA
Chicago
ICMJE
MLA
NLM
Reches, A., Wagner, H. R., Jackson-Lewis, V., Yablonskaya-Alter, E., & Fahn, S. (1984). Chronic levodopa or pergolide administration induces down-regulation of dopamine receptors in denervated striatum. Neurology, 34(9), 1208–1212. https://doi.org/10.1212/wnl.34.9.1208
Reches, A., H. R. Wagner, V. Jackson-Lewis, E. Yablonskaya-Alter, and S. Fahn. “Chronic levodopa or pergolide administration induces down-regulation of dopamine receptors in denervated striatum.” Neurology 34, no. 9 (September 1984): 1208–12. https://doi.org/10.1212/wnl.34.9.1208.
Reches A, Wagner HR, Jackson-Lewis V, Yablonskaya-Alter E, Fahn S. Chronic levodopa or pergolide administration induces down-regulation of dopamine receptors in denervated striatum. Neurology. 1984 Sep;34(9):1208–12.
Reches, A., et al. “Chronic levodopa or pergolide administration induces down-regulation of dopamine receptors in denervated striatum.” Neurology, vol. 34, no. 9, Sept. 1984, pp. 1208–12. Pubmed, doi:10.1212/wnl.34.9.1208.
Reches A, Wagner HR, Jackson-Lewis V, Yablonskaya-Alter E, Fahn S. Chronic levodopa or pergolide administration induces down-regulation of dopamine receptors in denervated striatum. Neurology. 1984 Sep;34(9):1208–1212.
Published In
Neurology
DOI
ISSN
0028-3878
Publication Date
September 1984
Volume
34
Issue
9
Start / End Page
1208 / 1212
Location
United States
Related Subject Headings
- Receptors, Dopamine
- Rats, Inbred Strains
- Rats
- Pergolide
- Parkinson Disease
- Neurology & Neurosurgery
- Male
- Levodopa
- Ergolines
- Denervation