Skip to main content
Journal cover image

A national clinical decision support infrastructure to enable the widespread and consistent practice of genomic and personalized medicine.

Publication ,  Journal Article
Kawamoto, K; Lobach, DF; Willard, HF; Ginsburg, GS
Published in: BMC Med Inform Decis Mak
March 23, 2009

BACKGROUND: In recent years, the completion of the Human Genome Project and other rapid advances in genomics have led to increasing anticipation of an era of genomic and personalized medicine, in which an individual's health is optimized through the use of all available patient data, including data on the individual's genome and its downstream products. Genomic and personalized medicine could transform healthcare systems and catalyze significant reductions in morbidity, mortality, and overall healthcare costs. DISCUSSION: Critical to the achievement of more efficient and effective healthcare enabled by genomics is the establishment of a robust, nationwide clinical decision support infrastructure that assists clinicians in their use of genomic assays to guide disease prevention, diagnosis, and therapy. Requisite components of this infrastructure include the standardized representation of genomic and non-genomic patient data across health information systems; centrally managed repositories of computer-processable medical knowledge; and standardized approaches for applying these knowledge resources against patient data to generate and deliver patient-specific care recommendations. Here, we provide recommendations for establishing a national decision support infrastructure for genomic and personalized medicine that fulfills these needs, leverages existing resources, and is aligned with the Roadmap for National Action on Clinical Decision Support commissioned by the U.S. Office of the National Coordinator for Health Information Technology. Critical to the establishment of this infrastructure will be strong leadership and substantial funding from the federal government. SUMMARY: A national clinical decision support infrastructure will be required for reaping the full benefits of genomic and personalized medicine. Essential components of this infrastructure include standards for data representation; centrally managed knowledge repositories; and standardized approaches for leveraging these knowledge repositories to generate patient-specific care recommendations at the point of care.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

BMC Med Inform Decis Mak

DOI

EISSN

1472-6947

Publication Date

March 23, 2009

Volume

9

Start / End Page

17

Location

England

Related Subject Headings

  • United States
  • Personal Health Services
  • Medical Informatics
  • Information Systems
  • Humans
  • Genomics
  • Genome, Human
  • Decision Support Systems, Clinical
  • Decision Making, Computer-Assisted
  • Databases as Topic
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kawamoto, K., Lobach, D. F., Willard, H. F., & Ginsburg, G. S. (2009). A national clinical decision support infrastructure to enable the widespread and consistent practice of genomic and personalized medicine. BMC Med Inform Decis Mak, 9, 17. https://doi.org/10.1186/1472-6947-9-17
Kawamoto, Kensaku, David F. Lobach, Huntington F. Willard, and Geoffrey S. Ginsburg. “A national clinical decision support infrastructure to enable the widespread and consistent practice of genomic and personalized medicine.BMC Med Inform Decis Mak 9 (March 23, 2009): 17. https://doi.org/10.1186/1472-6947-9-17.
Kawamoto K, Lobach DF, Willard HF, Ginsburg GS. A national clinical decision support infrastructure to enable the widespread and consistent practice of genomic and personalized medicine. BMC Med Inform Decis Mak. 2009 Mar 23;9:17.
Kawamoto, Kensaku, et al. “A national clinical decision support infrastructure to enable the widespread and consistent practice of genomic and personalized medicine.BMC Med Inform Decis Mak, vol. 9, Mar. 2009, p. 17. Pubmed, doi:10.1186/1472-6947-9-17.
Kawamoto K, Lobach DF, Willard HF, Ginsburg GS. A national clinical decision support infrastructure to enable the widespread and consistent practice of genomic and personalized medicine. BMC Med Inform Decis Mak. 2009 Mar 23;9:17.
Journal cover image

Published In

BMC Med Inform Decis Mak

DOI

EISSN

1472-6947

Publication Date

March 23, 2009

Volume

9

Start / End Page

17

Location

England

Related Subject Headings

  • United States
  • Personal Health Services
  • Medical Informatics
  • Information Systems
  • Humans
  • Genomics
  • Genome, Human
  • Decision Support Systems, Clinical
  • Decision Making, Computer-Assisted
  • Databases as Topic