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Effects of pentoxifylline on the cardiovascular manifestations of group B streptococcal sepsis in the piglet.

Publication ,  Journal Article
Del Moral, T; Goldberg, RN; Suguihara, C; Martinez, O; Feuer, WJ; Bancalari, E
Published in: Pediatr Res
June 1992

Pentoxifylline (PTXF) is a methylxanthine that modifies leukocyte function and inhibits cytokine release. To evaluate its effects on the cardiovascular manifestations of sepsis secondary to group B streptococci, 14 anesthetized, mechanically ventilated piglets were studied over a 240-min period. Animals were randomly assigned to a treatment group that received a PTXF bolus (20 mg/kg) followed by a continuous infusion of 5 mg/kg/h before and during group B streptococci (1 x 10(8) colony forming units/kg/min) administration and a control group that received saline as a placebo. Comparison of the hemodynamic measurements and arterial blood gases during the first 90 min of PTXF treatment with those of the control group resulted in the following 90 min values: systemic arterial blood pressure was significantly higher in the PTXF group (89 +/- 10 versus 56 +/- 30 mm Hg; p less than 0.005) as was cardiac output (0.18 +/- 0.04 versus 0.10 +/- 0.07 L/kg/min; p less than 0.005). Pulmonary vascular resistance remained lower in the PTXF-treated animals (135 +/- 117 versus 248 +/- 119 mm Hg/L/min/kg; p less than 0.001), and these animals were less acidotic as measured by pH (7.07 +/- 0.2 versus 7.31 +/- 0.1; p less than 0.05) and base deficit (-15 +/- 9 versus -5 +/- 2 mmol/L; p less than 0.05). Median survival time was significantly longer in the PTXF group (210 versus 90 min; p less than 0.002). These data demonstrate that PTXF can ameliorate some of the deleterious hemodynamic manifestations of group B streptococci sepsis and result in improved survival in a young animal model.

Duke Scholars

Published In

Pediatr Res

DOI

ISSN

0031-3998

Publication Date

June 1992

Volume

31

Issue

6

Start / End Page

596 / 600

Location

United States

Related Subject Headings

  • Vascular Resistance
  • Swine
  • Streptococcus agalactiae
  • Streptococcal Infections
  • Pentoxifylline
  • Pediatrics
  • Hemodynamics
  • Dose-Response Relationship, Drug
  • Cardiovascular System
  • Cardiac Output
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Del Moral, T., Goldberg, R. N., Suguihara, C., Martinez, O., Feuer, W. J., & Bancalari, E. (1992). Effects of pentoxifylline on the cardiovascular manifestations of group B streptococcal sepsis in the piglet. Pediatr Res, 31(6), 596–600. https://doi.org/10.1203/00006450-199206000-00012
Del Moral, T., R. N. Goldberg, C. Suguihara, O. Martinez, W. J. Feuer, and E. Bancalari. “Effects of pentoxifylline on the cardiovascular manifestations of group B streptococcal sepsis in the piglet.Pediatr Res 31, no. 6 (June 1992): 596–600. https://doi.org/10.1203/00006450-199206000-00012.
Del Moral T, Goldberg RN, Suguihara C, Martinez O, Feuer WJ, Bancalari E. Effects of pentoxifylline on the cardiovascular manifestations of group B streptococcal sepsis in the piglet. Pediatr Res. 1992 Jun;31(6):596–600.
Del Moral, T., et al. “Effects of pentoxifylline on the cardiovascular manifestations of group B streptococcal sepsis in the piglet.Pediatr Res, vol. 31, no. 6, June 1992, pp. 596–600. Pubmed, doi:10.1203/00006450-199206000-00012.
Del Moral T, Goldberg RN, Suguihara C, Martinez O, Feuer WJ, Bancalari E. Effects of pentoxifylline on the cardiovascular manifestations of group B streptococcal sepsis in the piglet. Pediatr Res. 1992 Jun;31(6):596–600.

Published In

Pediatr Res

DOI

ISSN

0031-3998

Publication Date

June 1992

Volume

31

Issue

6

Start / End Page

596 / 600

Location

United States

Related Subject Headings

  • Vascular Resistance
  • Swine
  • Streptococcus agalactiae
  • Streptococcal Infections
  • Pentoxifylline
  • Pediatrics
  • Hemodynamics
  • Dose-Response Relationship, Drug
  • Cardiovascular System
  • Cardiac Output