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Influence of group B streptococci on piglet pulmonary artery response to bradykinin.

Publication ,  Journal Article
Whitehurst, RM; Laskey, R; Goldberg, RN; Herbert, D; Van Breemen, C
Published in: J Appl Physiol (1985)
January 1999

To study whether a sepsis-induced increase in des-Arg9-bradykinin (des-Arg9-BK) and bradykinin (BK) B1-receptor activity participates in the observed increase in pulmonary vascular resistance in neonatal group B streptococcal sepsis (GBS), isometric force bioassays of pulmonary artery (PA) rings were studied, after 4-h exposure to either Krebs or GBS, by using the following protocols: 1) BK dose-response curve, 2) vascular response to BK with NG-nitro-L-arginine methyl ester (L-NAME), and 3) response to des-Arg9-BK (BK metabolite and B1 agonist). PA rings exposed to BK resulted in contraction in the GBS group and a decrease in resting tension in the Control group (P = 0.034) at a concentration of 10(-5) M. GBS-treated PA rings contracted more to des-Arg9-BK than did Controls (P < 0.001). BK (10(-6) M) relaxed preconstricted PA rings incubated in GBS less than BK relaxed Controls (P < 0.001), and preincubation with L-NAME decreased relaxation in both. These results suggest that GBS decreased endothelium-dependent BK relaxation and increased contractile response to des-Arg9-BK. We speculate that this occurs secondary to upregulation of B1 receptors reflected by B1-agonist-mediated PA contraction.

Duke Scholars

Published In

J Appl Physiol (1985)

DOI

ISSN

8750-7587

Publication Date

January 1999

Volume

86

Issue

1

Start / End Page

61 / 65

Location

United States

Related Subject Headings

  • Swine
  • Streptococcus agalactiae
  • Streptococcal Infections
  • Pulmonary Artery
  • Physiology
  • Nitric Oxide Synthase Type III
  • Nitric Oxide Synthase
  • NG-Nitroarginine Methyl Ester
  • Muscle Contraction
  • In Vitro Techniques
 

Citation

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Whitehurst, R. M., Laskey, R., Goldberg, R. N., Herbert, D., & Van Breemen, C. (1999). Influence of group B streptococci on piglet pulmonary artery response to bradykinin. J Appl Physiol (1985), 86(1), 61–65. https://doi.org/10.1152/jappl.1999.86.1.61
Whitehurst, R. M., R. Laskey, R. N. Goldberg, D. Herbert, and C. Van Breemen. “Influence of group B streptococci on piglet pulmonary artery response to bradykinin.J Appl Physiol (1985) 86, no. 1 (January 1999): 61–65. https://doi.org/10.1152/jappl.1999.86.1.61.
Whitehurst RM, Laskey R, Goldberg RN, Herbert D, Van Breemen C. Influence of group B streptococci on piglet pulmonary artery response to bradykinin. J Appl Physiol (1985). 1999 Jan;86(1):61–5.
Whitehurst, R. M., et al. “Influence of group B streptococci on piglet pulmonary artery response to bradykinin.J Appl Physiol (1985), vol. 86, no. 1, Jan. 1999, pp. 61–65. Pubmed, doi:10.1152/jappl.1999.86.1.61.
Whitehurst RM, Laskey R, Goldberg RN, Herbert D, Van Breemen C. Influence of group B streptococci on piglet pulmonary artery response to bradykinin. J Appl Physiol (1985). 1999 Jan;86(1):61–65.

Published In

J Appl Physiol (1985)

DOI

ISSN

8750-7587

Publication Date

January 1999

Volume

86

Issue

1

Start / End Page

61 / 65

Location

United States

Related Subject Headings

  • Swine
  • Streptococcus agalactiae
  • Streptococcal Infections
  • Pulmonary Artery
  • Physiology
  • Nitric Oxide Synthase Type III
  • Nitric Oxide Synthase
  • NG-Nitroarginine Methyl Ester
  • Muscle Contraction
  • In Vitro Techniques