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Leptomeningeal dissemination of optic pathway gliomas in three children.

Publication ,  Journal Article
Bruggers, CS; Friedman, HS; Phillips, PC; Wiener, MD; Hockenberger, B; Oakes, WJ; Buckley, EG
Published in: Am J Ophthalmol
June 15, 1991

We treated three children with optic pathway gliomas who had progressive disease associated with metastatic spread to the leptomeninges. One patient had radiographic resolution of leptomeningeal disease after treatment with intravenous carmustine and oral mercaptopurine but died of progressive pulmonary fibrosis. The second patient was treated with intravenous thiotepa, and the leptomeningeal disease remained stable. The third patient was treated with intravenous vincristine sulfate, cyclophosphamide, cisplatin, and etoposide and had a significant size reduction of the leptomeningeal lesion. Although leptomeningeal dissemination is a seemingly rare event, it is important that all children with optic pathway gliomas be considered for this possibility, particularly after the onset of new, atypical neurologic symptoms.

Duke Scholars

Published In

Am J Ophthalmol

DOI

ISSN

0002-9394

Publication Date

June 15, 1991

Volume

111

Issue

6

Start / End Page

719 / 723

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Pia Mater
  • Optic Chiasm
  • Ophthalmology & Optometry
  • Meningeal Neoplasms
  • Male
  • Magnetic Resonance Imaging
  • Infant
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Bruggers, C. S., Friedman, H. S., Phillips, P. C., Wiener, M. D., Hockenberger, B., Oakes, W. J., & Buckley, E. G. (1991). Leptomeningeal dissemination of optic pathway gliomas in three children. Am J Ophthalmol, 111(6), 719–723. https://doi.org/10.1016/s0002-9394(14)76778-9
Bruggers, C. S., H. S. Friedman, P. C. Phillips, M. D. Wiener, B. Hockenberger, W. J. Oakes, and E. G. Buckley. “Leptomeningeal dissemination of optic pathway gliomas in three children.Am J Ophthalmol 111, no. 6 (June 15, 1991): 719–23. https://doi.org/10.1016/s0002-9394(14)76778-9.
Bruggers CS, Friedman HS, Phillips PC, Wiener MD, Hockenberger B, Oakes WJ, et al. Leptomeningeal dissemination of optic pathway gliomas in three children. Am J Ophthalmol. 1991 Jun 15;111(6):719–23.
Bruggers, C. S., et al. “Leptomeningeal dissemination of optic pathway gliomas in three children.Am J Ophthalmol, vol. 111, no. 6, June 1991, pp. 719–23. Pubmed, doi:10.1016/s0002-9394(14)76778-9.
Bruggers CS, Friedman HS, Phillips PC, Wiener MD, Hockenberger B, Oakes WJ, Buckley EG. Leptomeningeal dissemination of optic pathway gliomas in three children. Am J Ophthalmol. 1991 Jun 15;111(6):719–723.
Journal cover image

Published In

Am J Ophthalmol

DOI

ISSN

0002-9394

Publication Date

June 15, 1991

Volume

111

Issue

6

Start / End Page

719 / 723

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Pia Mater
  • Optic Chiasm
  • Ophthalmology & Optometry
  • Meningeal Neoplasms
  • Male
  • Magnetic Resonance Imaging
  • Infant
  • Humans
  • Female