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Adult-onset primary open angle glaucoma does not localize to chromosome 2cen-q13 in North American families.

Publication ,  Journal Article
Allingham, RR; Wiggs, JL; Damji, KF; Herndon, L; Youn, J; Tallett, DA; Jones, KH; Del Bono, EA; Reardon, M; Haines, JL; Pericak-Vance, MA
Published in: Hum Hered
1998

Glaucoma is one of the leading causes of irreversible blindness in the world and is characterized by elevated intraocular pressure, optic nerve atrophy, and progressive visual field loss. Primary open angle glaucoma (POAG) is the most common subtype of glaucoma in the United States. Recently, Stoilova and coworkers [Genomics 1996;36:142-150] identified a locus for POAG on chromosome 2 (2cen-q13) in families primarily located in the United Kingdom. We examined families with POAG identified within the US for linkage to the 2cen-q13 locus. A total of 18 families with POAG were used in the analysis. Of 77 family members, 46 were classified as affected and 31 were either glaucoma suspects or considered normal. Eight highly polymorphic and informative markers flanking and distributed throughout the region were used. Parametric lod score analysis was performed using both a dominant and recessive low penetrance or 'affecteds-only' model. Multipoint affected sibpair exclusion mapping was also performed. Lod score (both models) and sibpair analysis excluded linkage of the POAG phenotype to the 2cen-q13 region in these families. These data suggest that the chromosome 2cen-q13 locus does not explain a substantial amount of genetic variation in familial POAG.

Duke Scholars

Published In

Hum Hered

DOI

ISSN

0001-5652

Publication Date

1998

Volume

48

Issue

5

Start / End Page

251 / 255

Location

Switzerland

Related Subject Headings

  • North America
  • Humans
  • Glaucoma, Open-Angle
  • Genetics & Heredity
  • Genetic Linkage
  • Chromosomes, Human, Pair 2
  • Chromosome Mapping
  • Age of Onset
  • Adult
  • 3105 Genetics
 

Citation

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Allingham, R. R., Wiggs, J. L., Damji, K. F., Herndon, L., Youn, J., Tallett, D. A., … Pericak-Vance, M. A. (1998). Adult-onset primary open angle glaucoma does not localize to chromosome 2cen-q13 in North American families. Hum Hered, 48(5), 251–255. https://doi.org/10.1159/000022812
Allingham, R. R., J. L. Wiggs, K. F. Damji, L. Herndon, J. Youn, D. A. Tallett, K. H. Jones, et al. “Adult-onset primary open angle glaucoma does not localize to chromosome 2cen-q13 in North American families.Hum Hered 48, no. 5 (1998): 251–55. https://doi.org/10.1159/000022812.
Allingham RR, Wiggs JL, Damji KF, Herndon L, Youn J, Tallett DA, et al. Adult-onset primary open angle glaucoma does not localize to chromosome 2cen-q13 in North American families. Hum Hered. 1998;48(5):251–5.
Allingham, R. R., et al. “Adult-onset primary open angle glaucoma does not localize to chromosome 2cen-q13 in North American families.Hum Hered, vol. 48, no. 5, 1998, pp. 251–55. Pubmed, doi:10.1159/000022812.
Allingham RR, Wiggs JL, Damji KF, Herndon L, Youn J, Tallett DA, Jones KH, Del Bono EA, Reardon M, Haines JL, Pericak-Vance MA. Adult-onset primary open angle glaucoma does not localize to chromosome 2cen-q13 in North American families. Hum Hered. 1998;48(5):251–255.
Journal cover image

Published In

Hum Hered

DOI

ISSN

0001-5652

Publication Date

1998

Volume

48

Issue

5

Start / End Page

251 / 255

Location

Switzerland

Related Subject Headings

  • North America
  • Humans
  • Glaucoma, Open-Angle
  • Genetics & Heredity
  • Genetic Linkage
  • Chromosomes, Human, Pair 2
  • Chromosome Mapping
  • Age of Onset
  • Adult
  • 3105 Genetics