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Abnormal production of interleukin-1 by microglia from trisomy 16 mice.

Publication ,  Journal Article
Colton, CA; Yao, J; Taffs, RE; Keri, JE; Oster-Granite, ML
Published in: Neurosci Lett
November 11, 1991

The production of interleukin-1 (IL-1) was examined in cultured CNS microglia obtained from trisomy 16 (Ts16) fetal mouse brain, a model system for studies relevant to Down syndrome (DS). When compared to microglia from their normal littermates, Ts16 microglia produced significantly higher levels of IL-1 activity both before and following stimulation with lipopolysaccharide (LPS). IL-1 release was stimulated by alpha/beta interferon (IFN) in the normal but not Ts16 microglial cultures. The overall level of IL-1 production in normal littermates, however, was still less than that seen in Ts16. Thus, microglia from Ts16 mice may function in an inappropriate manner and, if this abnormality occurs in vivo, may have wide ranging effects on a developing nervous system.

Duke Scholars

Published In

Neurosci Lett

DOI

ISSN

0304-3940

Publication Date

November 11, 1991

Volume

132

Issue

2

Start / End Page

270 / 274

Location

Ireland

Related Subject Headings

  • Trisomy
  • Reference Values
  • Neuroglia
  • Mice
  • Lipopolysaccharides
  • Interleukin-1
  • Interferons
  • Humans
  • Endotoxins
  • Down Syndrome
 

Citation

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ICMJE
MLA
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Colton, C. A., Yao, J., Taffs, R. E., Keri, J. E., & Oster-Granite, M. L. (1991). Abnormal production of interleukin-1 by microglia from trisomy 16 mice. Neurosci Lett, 132(2), 270–274. https://doi.org/10.1016/0304-3940(91)90318-n
Colton, C. A., J. Yao, R. E. Taffs, J. E. Keri, and M. L. Oster-Granite. “Abnormal production of interleukin-1 by microglia from trisomy 16 mice.Neurosci Lett 132, no. 2 (November 11, 1991): 270–74. https://doi.org/10.1016/0304-3940(91)90318-n.
Colton CA, Yao J, Taffs RE, Keri JE, Oster-Granite ML. Abnormal production of interleukin-1 by microglia from trisomy 16 mice. Neurosci Lett. 1991 Nov 11;132(2):270–4.
Colton, C. A., et al. “Abnormal production of interleukin-1 by microglia from trisomy 16 mice.Neurosci Lett, vol. 132, no. 2, Nov. 1991, pp. 270–74. Pubmed, doi:10.1016/0304-3940(91)90318-n.
Colton CA, Yao J, Taffs RE, Keri JE, Oster-Granite ML. Abnormal production of interleukin-1 by microglia from trisomy 16 mice. Neurosci Lett. 1991 Nov 11;132(2):270–274.
Journal cover image

Published In

Neurosci Lett

DOI

ISSN

0304-3940

Publication Date

November 11, 1991

Volume

132

Issue

2

Start / End Page

270 / 274

Location

Ireland

Related Subject Headings

  • Trisomy
  • Reference Values
  • Neuroglia
  • Mice
  • Lipopolysaccharides
  • Interleukin-1
  • Interferons
  • Humans
  • Endotoxins
  • Down Syndrome