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Changes in synaptic transmission produced by hydrogen peroxide.

Publication ,  Journal Article
Colton, CA; Colton, JS; Gilbert, DL
Published in: J Free Radic Biol Med
1986

The effect of hydrogen peroxide (H2O2) on excitatory and inhibitory synaptic transmission was studied at the lobster neuromuscular junction. H2O2 produced a dose dependent decrease in the amplitude of the junction potential (Vejp). This decrease was due to changes in both presynaptic transmitter release and the postsynaptic response to the neurotransmitter. Observed presynaptic changes due to exposure to H2O2 were a decrease in the amount of transmitter released, that is, quantal content, as well as a decrease in the fast facilitation, that is, the amplitude increase of successive excitatory junction potentials at a rate of 3 Hz. To discern postsynaptic changes, glutamate, the putative excitatory neurotransmitter for this preparation was applied directly to the bathing medium in order to bypass the presynaptic release process. H2O2 produced a decreased response of the glutamate receptor/ionophore. The action of H2O2 was not selective to excitatory (glutamate-mediated) transmission because inhibitory (GABA-mediated) transmission was also depressed by H2O2. This effect was primarily presynaptic since H2O2 produced no change in the postsynaptic response to applied GABA.

Duke Scholars

Published In

J Free Radic Biol Med

DOI

ISSN

0748-5514

Publication Date

1986

Volume

2

Issue

2

Start / End Page

141 / 148

Location

United States

Related Subject Headings

  • tert-Butylhydroperoxide
  • gamma-Aminobutyric Acid
  • Synaptic Transmission
  • Synaptic Membranes
  • Peroxides
  • Neuromuscular Junction
  • Neural Inhibition
  • Nephropidae
  • Membrane Potentials
  • Hydrogen Peroxide
 

Citation

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Colton, C. A., Colton, J. S., & Gilbert, D. L. (1986). Changes in synaptic transmission produced by hydrogen peroxide. J Free Radic Biol Med, 2(2), 141–148. https://doi.org/10.1016/s0748-5514(86)80063-0
Colton, C. A., J. S. Colton, and D. L. Gilbert. “Changes in synaptic transmission produced by hydrogen peroxide.J Free Radic Biol Med 2, no. 2 (1986): 141–48. https://doi.org/10.1016/s0748-5514(86)80063-0.
Colton CA, Colton JS, Gilbert DL. Changes in synaptic transmission produced by hydrogen peroxide. J Free Radic Biol Med. 1986;2(2):141–8.
Colton, C. A., et al. “Changes in synaptic transmission produced by hydrogen peroxide.J Free Radic Biol Med, vol. 2, no. 2, 1986, pp. 141–48. Pubmed, doi:10.1016/s0748-5514(86)80063-0.
Colton CA, Colton JS, Gilbert DL. Changes in synaptic transmission produced by hydrogen peroxide. J Free Radic Biol Med. 1986;2(2):141–148.

Published In

J Free Radic Biol Med

DOI

ISSN

0748-5514

Publication Date

1986

Volume

2

Issue

2

Start / End Page

141 / 148

Location

United States

Related Subject Headings

  • tert-Butylhydroperoxide
  • gamma-Aminobutyric Acid
  • Synaptic Transmission
  • Synaptic Membranes
  • Peroxides
  • Neuromuscular Junction
  • Neural Inhibition
  • Nephropidae
  • Membrane Potentials
  • Hydrogen Peroxide