Phenobarbital does not alter phenytoin steady-state serum concentration or pharmacokinetics.
Publication
, Journal Article
Browne, TR; Szabo, GK; Evans, J; Evans, BA; Greenblatt, DJ; Mikati, MA
Published in: Neurology
April 1988
Phenytoin pharmacokinetics and biotransformation were studied with stable isotope tracer techniques in six patients before and after addition of phenobarbital. No significant (p less than 0.05) changes in phenytoin serum concentration, clearance, elimination half-life, volume of distribution, or clearance via production of p-hydroxyphenyl-phenylhydantoin or phenytoin dihydrodiol occurred after addition of phenobarbital. Thus, frequent phenytoin serum concentration determinations or a change in phenytoin dosing rate are probably not necessary after adding phenobarbital.
Duke Scholars
Published In
Neurology
DOI
ISSN
0028-3878
Publication Date
April 1988
Volume
38
Issue
4
Start / End Page
639 / 642
Location
United States
Related Subject Headings
- Phenytoin
- Phenobarbital
- Neurology & Neurosurgery
- Middle Aged
- Male
- Humans
- Epilepsy
- Aged
- Adult
- 3209 Neurosciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Browne, T. R., Szabo, G. K., Evans, J., Evans, B. A., Greenblatt, D. J., & Mikati, M. A. (1988). Phenobarbital does not alter phenytoin steady-state serum concentration or pharmacokinetics. Neurology, 38(4), 639–642. https://doi.org/10.1212/wnl.38.4.639
Browne, T. R., G. K. Szabo, J. Evans, B. A. Evans, D. J. Greenblatt, and M. A. Mikati. “Phenobarbital does not alter phenytoin steady-state serum concentration or pharmacokinetics.” Neurology 38, no. 4 (April 1988): 639–42. https://doi.org/10.1212/wnl.38.4.639.
Browne TR, Szabo GK, Evans J, Evans BA, Greenblatt DJ, Mikati MA. Phenobarbital does not alter phenytoin steady-state serum concentration or pharmacokinetics. Neurology. 1988 Apr;38(4):639–42.
Browne, T. R., et al. “Phenobarbital does not alter phenytoin steady-state serum concentration or pharmacokinetics.” Neurology, vol. 38, no. 4, Apr. 1988, pp. 639–42. Pubmed, doi:10.1212/wnl.38.4.639.
Browne TR, Szabo GK, Evans J, Evans BA, Greenblatt DJ, Mikati MA. Phenobarbital does not alter phenytoin steady-state serum concentration or pharmacokinetics. Neurology. 1988 Apr;38(4):639–642.
Published In
Neurology
DOI
ISSN
0028-3878
Publication Date
April 1988
Volume
38
Issue
4
Start / End Page
639 / 642
Location
United States
Related Subject Headings
- Phenytoin
- Phenobarbital
- Neurology & Neurosurgery
- Middle Aged
- Male
- Humans
- Epilepsy
- Aged
- Adult
- 3209 Neurosciences