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Phenobarbital does not alter phenytoin steady-state serum concentration or pharmacokinetics.

Publication ,  Journal Article
Browne, TR; Szabo, GK; Evans, J; Evans, BA; Greenblatt, DJ; Mikati, MA
Published in: Neurology
April 1988

Phenytoin pharmacokinetics and biotransformation were studied with stable isotope tracer techniques in six patients before and after addition of phenobarbital. No significant (p less than 0.05) changes in phenytoin serum concentration, clearance, elimination half-life, volume of distribution, or clearance via production of p-hydroxyphenyl-phenylhydantoin or phenytoin dihydrodiol occurred after addition of phenobarbital. Thus, frequent phenytoin serum concentration determinations or a change in phenytoin dosing rate are probably not necessary after adding phenobarbital.

Duke Scholars

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

April 1988

Volume

38

Issue

4

Start / End Page

639 / 642

Location

United States

Related Subject Headings

  • Phenytoin
  • Phenobarbital
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Epilepsy
  • Aged
  • Adult
  • 3209 Neurosciences
 

Citation

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ICMJE
MLA
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Browne, T. R., Szabo, G. K., Evans, J., Evans, B. A., Greenblatt, D. J., & Mikati, M. A. (1988). Phenobarbital does not alter phenytoin steady-state serum concentration or pharmacokinetics. Neurology, 38(4), 639–642. https://doi.org/10.1212/wnl.38.4.639
Browne, T. R., G. K. Szabo, J. Evans, B. A. Evans, D. J. Greenblatt, and M. A. Mikati. “Phenobarbital does not alter phenytoin steady-state serum concentration or pharmacokinetics.Neurology 38, no. 4 (April 1988): 639–42. https://doi.org/10.1212/wnl.38.4.639.
Browne TR, Szabo GK, Evans J, Evans BA, Greenblatt DJ, Mikati MA. Phenobarbital does not alter phenytoin steady-state serum concentration or pharmacokinetics. Neurology. 1988 Apr;38(4):639–42.
Browne, T. R., et al. “Phenobarbital does not alter phenytoin steady-state serum concentration or pharmacokinetics.Neurology, vol. 38, no. 4, Apr. 1988, pp. 639–42. Pubmed, doi:10.1212/wnl.38.4.639.
Browne TR, Szabo GK, Evans J, Evans BA, Greenblatt DJ, Mikati MA. Phenobarbital does not alter phenytoin steady-state serum concentration or pharmacokinetics. Neurology. 1988 Apr;38(4):639–642.

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

April 1988

Volume

38

Issue

4

Start / End Page

639 / 642

Location

United States

Related Subject Headings

  • Phenytoin
  • Phenobarbital
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Epilepsy
  • Aged
  • Adult
  • 3209 Neurosciences