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Cerebral sinus thrombosis in a patient with humoral immunodeficiency on intravenous immunoglobulin therapy: a case report.

Publication ,  Journal Article
Barada, W; Muwakkit, S; Hourani, R; Bitar, M; Mikati, M
Published in: Neuropediatrics
April 2008

We present the case of an 11-year-old boy with humoral immunodeficiency on monthly intravenous immunoglobulins (IVIG) infusions, evaluated for recurrent, brief, neurological deficits secondary to cerebral sinus thrombosis without any identifiable hypercoagulability state. Etiologic possibilities for the thrombotic event are presented with special discussion of IVIG-related cerebral thrombosis. To the best of our knowledge, our patient represents the first reported case of Bruton's disease on IVIG therapy developing a cerebral ischemic event and the second reported case of cerebral sinus thrombosis associated with IVIG use for any disease. Potential concerns regarding the risk of cerebral thrombosis during IVIG therapy in this and other disorders are reviewed.

Duke Scholars

Published In

Neuropediatrics

DOI

ISSN

0174-304X

Publication Date

April 2008

Volume

39

Issue

2

Start / End Page

131 / 133

Location

Germany

Related Subject Headings

  • Tomography, X-Ray Computed
  • Sinus Thrombosis, Intracranial
  • Phlebography
  • Neurology & Neurosurgery
  • Male
  • Immunologic Deficiency Syndromes
  • Immunoglobulins, Intravenous
  • Humans
  • Child
  • 3213 Paediatrics
 

Citation

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Chicago
ICMJE
MLA
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Barada, W., Muwakkit, S., Hourani, R., Bitar, M., & Mikati, M. (2008). Cerebral sinus thrombosis in a patient with humoral immunodeficiency on intravenous immunoglobulin therapy: a case report. Neuropediatrics, 39(2), 131–133. https://doi.org/10.1055/s-2008-1077088
Barada, W., S. Muwakkit, R. Hourani, M. Bitar, and M. Mikati. “Cerebral sinus thrombosis in a patient with humoral immunodeficiency on intravenous immunoglobulin therapy: a case report.Neuropediatrics 39, no. 2 (April 2008): 131–33. https://doi.org/10.1055/s-2008-1077088.
Barada W, Muwakkit S, Hourani R, Bitar M, Mikati M. Cerebral sinus thrombosis in a patient with humoral immunodeficiency on intravenous immunoglobulin therapy: a case report. Neuropediatrics. 2008 Apr;39(2):131–3.
Barada, W., et al. “Cerebral sinus thrombosis in a patient with humoral immunodeficiency on intravenous immunoglobulin therapy: a case report.Neuropediatrics, vol. 39, no. 2, Apr. 2008, pp. 131–33. Pubmed, doi:10.1055/s-2008-1077088.
Barada W, Muwakkit S, Hourani R, Bitar M, Mikati M. Cerebral sinus thrombosis in a patient with humoral immunodeficiency on intravenous immunoglobulin therapy: a case report. Neuropediatrics. 2008 Apr;39(2):131–133.
Journal cover image

Published In

Neuropediatrics

DOI

ISSN

0174-304X

Publication Date

April 2008

Volume

39

Issue

2

Start / End Page

131 / 133

Location

Germany

Related Subject Headings

  • Tomography, X-Ray Computed
  • Sinus Thrombosis, Intracranial
  • Phlebography
  • Neurology & Neurosurgery
  • Male
  • Immunologic Deficiency Syndromes
  • Immunoglobulins, Intravenous
  • Humans
  • Child
  • 3213 Paediatrics