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Carbamazepine increases phenytoin serum concentration and reduces phenytoin clearance.

Publication ,  Journal Article
Browne, TR; Szabo, GK; Evans, JE; Evans, BA; Greenblatt, DJ; Mikati, MA
Published in: Neurology
July 1988
Published version (DOI) Link to item

Addition of carbamazepine to phenytoin monotherapy resulted in the following significant (p less than 0.05) changes: (1) increased mean phenytoin serum concentration; (2) decreased phenytoin clearance, due to decreased production of phenytoin dihydrodiol and p-hydroxyphenyl-phenylhydantoin; (3) increased phenytoin elimination half-life; and (4) increased drug-related toxicity. Close monitoring is required after addition of carbamazepine to phenytoin.

Duke Scholars

Mohamad Abdul Mikati
Author Mohamad Abdul Mikati Pediatrics, Neurology

Published In

Neurology

DOI

10.1212/wnl.38.7.1146

ISSN

0028-3878

Publication Date

July 1988

Volume

38

Issue

7

Start / End Page

1146 / 1150

Location

United States

Related Subject Headings

  • Time Factors
  • Phenytoin
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Epilepsy
  • Drug Therapy, Combination
  • Carbamazepine
  • Adult
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Browne, T. R., Szabo, G. K., Evans, J. E., Evans, B. A., Greenblatt, D. J., & Mikati, M. A. (1988). Carbamazepine increases phenytoin serum concentration and reduces phenytoin clearance. Neurology, 38(7), 1146–1150. https://doi.org/10.1212/wnl.38.7.1146
Browne, T. R., G. K. Szabo, J. E. Evans, B. A. Evans, D. J. Greenblatt, and M. A. Mikati. “Carbamazepine increases phenytoin serum concentration and reduces phenytoin clearance.” Neurology 38, no. 7 (July 1988): 1146–50. https://doi.org/10.1212/wnl.38.7.1146.
Browne TR, Szabo GK, Evans JE, Evans BA, Greenblatt DJ, Mikati MA. Carbamazepine increases phenytoin serum concentration and reduces phenytoin clearance. Neurology. 1988 Jul;38(7):1146–50.
Browne, T. R., et al. “Carbamazepine increases phenytoin serum concentration and reduces phenytoin clearance.” Neurology, vol. 38, no. 7, July 1988, pp. 1146–50. Pubmed, doi:10.1212/wnl.38.7.1146.
Browne TR, Szabo GK, Evans JE, Evans BA, Greenblatt DJ, Mikati MA. Carbamazepine increases phenytoin serum concentration and reduces phenytoin clearance. Neurology. 1988 Jul;38(7):1146–1150.

Published In

Neurology

DOI

10.1212/wnl.38.7.1146

ISSN

0028-3878

Publication Date

July 1988

Volume

38

Issue

7

Start / End Page

1146 / 1150

Location

United States

Related Subject Headings

  • Time Factors
  • Phenytoin
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Epilepsy
  • Drug Therapy, Combination
  • Carbamazepine
  • Adult