Effect of kainic acid-induced status epilepticus on inositol-trisphosphate and seizure-induced brain damage in mature and immature animals.
Publication
, Journal Article
Carmant, L; Liu, Z; Werner, SJ; Mikati, MA; Holmes, GL
Published in: Brain Res Dev Brain Res
October 27, 1995
We investigated the role of excitatory amino acids in the activation of the phosphoinositide pathway during kainic acid-induced seizures in mature and immature animals. Kainic acid caused more severe seizures in the immature animals, but no hippocampal damage or induction of phosphoinositide hydrolysis. In mature animals, seizures were mild but severe hippocampal damage was seen and was associated with a marked and sustained release of inositol-trisphosphate, suggesting a role of this pathway and intracellular calcium stores in seizure-induced brain damage.
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Published In
Brain Res Dev Brain Res
DOI
ISSN
0165-3806
Publication Date
October 27, 1995
Volume
89
Issue
1
Start / End Page
67 / 72
Location
Netherlands
Related Subject Headings
- Status Epilepticus
- Seizures
- Rats, Sprague-Dawley
- Rats
- Neurology & Neurosurgery
- Male
- Kainic Acid
- Inositol Phosphates
- Excitatory Amino Acids
- Brain Diseases
Citation
APA
Chicago
ICMJE
MLA
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Carmant, L., Liu, Z., Werner, S. J., Mikati, M. A., & Holmes, G. L. (1995). Effect of kainic acid-induced status epilepticus on inositol-trisphosphate and seizure-induced brain damage in mature and immature animals. Brain Res Dev Brain Res, 89(1), 67–72. https://doi.org/10.1016/0165-3806(95)00110-y
Carmant, L., Z. Liu, S. J. Werner, M. A. Mikati, and G. L. Holmes. “Effect of kainic acid-induced status epilepticus on inositol-trisphosphate and seizure-induced brain damage in mature and immature animals.” Brain Res Dev Brain Res 89, no. 1 (October 27, 1995): 67–72. https://doi.org/10.1016/0165-3806(95)00110-y.
Carmant L, Liu Z, Werner SJ, Mikati MA, Holmes GL. Effect of kainic acid-induced status epilepticus on inositol-trisphosphate and seizure-induced brain damage in mature and immature animals. Brain Res Dev Brain Res. 1995 Oct 27;89(1):67–72.
Carmant, L., et al. “Effect of kainic acid-induced status epilepticus on inositol-trisphosphate and seizure-induced brain damage in mature and immature animals.” Brain Res Dev Brain Res, vol. 89, no. 1, Oct. 1995, pp. 67–72. Pubmed, doi:10.1016/0165-3806(95)00110-y.
Carmant L, Liu Z, Werner SJ, Mikati MA, Holmes GL. Effect of kainic acid-induced status epilepticus on inositol-trisphosphate and seizure-induced brain damage in mature and immature animals. Brain Res Dev Brain Res. 1995 Oct 27;89(1):67–72.
Published In
Brain Res Dev Brain Res
DOI
ISSN
0165-3806
Publication Date
October 27, 1995
Volume
89
Issue
1
Start / End Page
67 / 72
Location
Netherlands
Related Subject Headings
- Status Epilepticus
- Seizures
- Rats, Sprague-Dawley
- Rats
- Neurology & Neurosurgery
- Male
- Kainic Acid
- Inositol Phosphates
- Excitatory Amino Acids
- Brain Diseases