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Racial differences in the interaction between family history and risk factors associated with diabetes in the National Health and Nutritional Examination Survey, 1999-2004.

Publication ,  Journal Article
Suchindran, S; Vana, AM; Shaffer, RA; Alcaraz, JE; McCarthy, JJ
Published in: Genet Med
July 2009

PURPOSE: We sought to determine whether the association between family history, a surrogate for genetic predisposition, and diabetes was modified by any known diabetes risk factors and if these relationships were constant across different ethnic groups. METHODS: We examined 10,899 adults from the National Health and Nutrition Examination Survey (1999 -2004) to identify interactions between family history and clinical, demographic, and lifestyle variables for the outcome of diabetes using logistic regression analysis in racial/ethnic subgroups. RESULTS: There was significant heterogeneity by race/ethnicity in the interaction between covariates and family history in relation to diabetes. In black (P = 0.0001) and Hispanic (P = 0.013), but not white (P = 0.75) subgroups, high-familial risk was a strong risk factor for diabetes among lean individuals but less so among overweight or obese subjects.Among blacks, high-familial risk conferred a 20-fold increased odds of diabetes among lean subjects and only a sixfold increased odds among obese individuals. CONCLUSIONS: These findings suggest possible race/ethnic-specific differences in gene by environment interaction and identify body mass index as an important effect modifier of familial risk in diabetes in non-white populations. These findings may help guide future genetic studies and improve the utility of family history as a public health screening tool.

Duke Scholars

Published In

Genet Med

DOI

EISSN

1530-0366

Publication Date

July 2009

Volume

11

Issue

7

Start / End Page

542 / 547

Location

United States

Related Subject Headings

  • White People
  • United States
  • Triglycerides
  • Risk Factors
  • Male
  • Logistic Models
  • Life Style
  • Humans
  • Hispanic or Latino
  • Genetics & Heredity
 

Citation

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ICMJE
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Suchindran, S., Vana, A. M., Shaffer, R. A., Alcaraz, J. E., & McCarthy, J. J. (2009). Racial differences in the interaction between family history and risk factors associated with diabetes in the National Health and Nutritional Examination Survey, 1999-2004. Genet Med, 11(7), 542–547. https://doi.org/10.1097/GIM.0b013e3181a70917
Suchindran, Sunil, Alicia M. Vana, Richard A. Shaffer, John E. Alcaraz, and Jeanette J. McCarthy. “Racial differences in the interaction between family history and risk factors associated with diabetes in the National Health and Nutritional Examination Survey, 1999-2004.Genet Med 11, no. 7 (July 2009): 542–47. https://doi.org/10.1097/GIM.0b013e3181a70917.
Suchindran, Sunil, et al. “Racial differences in the interaction between family history and risk factors associated with diabetes in the National Health and Nutritional Examination Survey, 1999-2004.Genet Med, vol. 11, no. 7, July 2009, pp. 542–47. Pubmed, doi:10.1097/GIM.0b013e3181a70917.

Published In

Genet Med

DOI

EISSN

1530-0366

Publication Date

July 2009

Volume

11

Issue

7

Start / End Page

542 / 547

Location

United States

Related Subject Headings

  • White People
  • United States
  • Triglycerides
  • Risk Factors
  • Male
  • Logistic Models
  • Life Style
  • Humans
  • Hispanic or Latino
  • Genetics & Heredity