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CT with a computer-simulated dose reduction technique for detection of pediatric nephroureterolithiasis: comparison of standard and reduced radiation doses.

Publication ,  Journal Article
Karmazyn, B; Frush, DP; Applegate, KE; Maxfield, C; Cohen, MD; Jones, RP
Published in: AJR Am J Roentgenol
January 2009

OBJECTIVE: The purpose of this study was to compare the diagnostic capabilities of standard- and reduced-dose CT in the detection of nephroureterolithiasis in children. MATERIALS AND METHODS: Forty-five patients 20 years old or younger divided into two groups weighing 50 kg or less and more than 50 kg underwent unenhanced 16-MDCT in the evaluation of acute flank pain. An investigational computer-simulated tube current reduction tool was used to produce additional 80- and 40-mA examination sets (total number of image sets=135). Three independent blinded readers ranked random images for stones (confidence scale, 1-5, least to most), hydronephrosis, noise-based image quality, and presence of nonrenal lesions. RESULTS: Compared with the standard tube current used for the original CT scans, there was no significant reduction (p=0.37) in detection of renal stones at the 80-mA setting (mean dose reduction, 67%; range, 43-81%); and at the 40-mA setting (mean dose reduction, 82%; range, 72-90%), the detection rate was significantly lower (p=0.05). At the 40-mA setting, there was no significant difference among the children weighing 50 kg or less (p=0.4). Detection of ureteral stones and hydronephrosis was not significantly different at 80 and 40 mA; however, disease frequency was low, and no definite conclusion can be made. CONCLUSION: Simulated dose reduction is a useful tool for determining diagnostic thresholds for MDCT detection of renal stones in children. Use of the 80-mA setting for all children and 40 mA for children weighing 50 kg or less does not significantly affect the diagnosis of pediatric renal stones.

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Published In

AJR Am J Roentgenol

DOI

EISSN

1546-3141

Publication Date

January 2009

Volume

192

Issue

1

Start / End Page

143 / 149

Location

United States

Related Subject Headings

  • Young Adult
  • Ureterolithiasis
  • Tomography, X-Ray Computed
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Radiation Dosage
  • Nuclear Medicine & Medical Imaging
  • Male
  • Kidney Calculi
  • Humans
 

Citation

APA
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MLA
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Karmazyn, B., Frush, D. P., Applegate, K. E., Maxfield, C., Cohen, M. D., & Jones, R. P. (2009). CT with a computer-simulated dose reduction technique for detection of pediatric nephroureterolithiasis: comparison of standard and reduced radiation doses. AJR Am J Roentgenol, 192(1), 143–149. https://doi.org/10.2214/AJR.08.1391
Karmazyn, Boaz, Donald P. Frush, Kimberly E. Applegate, Charles Maxfield, Mervyn D. Cohen, and Robert P. Jones. “CT with a computer-simulated dose reduction technique for detection of pediatric nephroureterolithiasis: comparison of standard and reduced radiation doses.AJR Am J Roentgenol 192, no. 1 (January 2009): 143–49. https://doi.org/10.2214/AJR.08.1391.
Karmazyn B, Frush DP, Applegate KE, Maxfield C, Cohen MD, Jones RP. CT with a computer-simulated dose reduction technique for detection of pediatric nephroureterolithiasis: comparison of standard and reduced radiation doses. AJR Am J Roentgenol. 2009 Jan;192(1):143–9.
Karmazyn, Boaz, et al. “CT with a computer-simulated dose reduction technique for detection of pediatric nephroureterolithiasis: comparison of standard and reduced radiation doses.AJR Am J Roentgenol, vol. 192, no. 1, Jan. 2009, pp. 143–49. Pubmed, doi:10.2214/AJR.08.1391.
Karmazyn B, Frush DP, Applegate KE, Maxfield C, Cohen MD, Jones RP. CT with a computer-simulated dose reduction technique for detection of pediatric nephroureterolithiasis: comparison of standard and reduced radiation doses. AJR Am J Roentgenol. 2009 Jan;192(1):143–149.

Published In

AJR Am J Roentgenol

DOI

EISSN

1546-3141

Publication Date

January 2009

Volume

192

Issue

1

Start / End Page

143 / 149

Location

United States

Related Subject Headings

  • Young Adult
  • Ureterolithiasis
  • Tomography, X-Ray Computed
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Radiation Dosage
  • Nuclear Medicine & Medical Imaging
  • Male
  • Kidney Calculi
  • Humans