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Tau--an inhibitor of deacetylase HDAC6 function.

Publication ,  Journal Article
Perez, M; Santa-Maria, I; Gomez de Barreda, E; Zhu, X; Cuadros, R; Cabrero, JR; Sanchez-Madrid, F; Dawson, HN; Vitek, MP; Perry, G; Smith, MA ...
Published in: J Neurochem
June 2009

Analysis of brain microtubule protein from patients with Alzheimer's disease showed decreased alpha tubulin levels along with increased acetylation of the alpha tubulin subunit, mainly in those microtubules from neurons containing neurofibrillary tau pathology. To determine the relationship of tau protein and increased tubulin acetylation, we studied the effect of tau on the acetylation-deacetylation of tubulin. Our results indicate that tau binds to the tubulin-deacetylase, histone deacetylase 6 (HDAC6), decreasing its activity with a consequent increase in tubulin acetylation. As expected, increased acetylation was also found in tubulin from wild-type mice compared with tubulin from mice lacking tau because of the tau-mediated inhibition of the deacetylase. In addition, we found that an excess of tau protein, as a HDAC6 inhibitor, prevents induction of autophagy by inhibiting proteasome function.

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Published In

J Neurochem

DOI

EISSN

1471-4159

Publication Date

June 2009

Volume

109

Issue

6

Start / End Page

1756 / 1766

Location

England

Related Subject Headings

  • tau Proteins
  • Tubulin
  • Transfection
  • Postmortem Changes
  • Neurons
  • Neurology & Neurosurgery
  • Microtubule-Associated Proteins
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
 

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Perez, M., Santa-Maria, I., Gomez de Barreda, E., Zhu, X., Cuadros, R., Cabrero, J. R., … Avila, J. (2009). Tau--an inhibitor of deacetylase HDAC6 function. J Neurochem, 109(6), 1756–1766. https://doi.org/10.1111/j.1471-4159.2009.06102.x
Perez, Mar, Ismael Santa-Maria, Elena Gomez de Barreda, Xiongwei Zhu, Raquel Cuadros, Jose Roman Cabrero, Francisco Sanchez-Madrid, et al. “Tau--an inhibitor of deacetylase HDAC6 function.J Neurochem 109, no. 6 (June 2009): 1756–66. https://doi.org/10.1111/j.1471-4159.2009.06102.x.
Perez M, Santa-Maria I, Gomez de Barreda E, Zhu X, Cuadros R, Cabrero JR, et al. Tau--an inhibitor of deacetylase HDAC6 function. J Neurochem. 2009 Jun;109(6):1756–66.
Perez, Mar, et al. “Tau--an inhibitor of deacetylase HDAC6 function.J Neurochem, vol. 109, no. 6, June 2009, pp. 1756–66. Pubmed, doi:10.1111/j.1471-4159.2009.06102.x.
Perez M, Santa-Maria I, Gomez de Barreda E, Zhu X, Cuadros R, Cabrero JR, Sanchez-Madrid F, Dawson HN, Vitek MP, Perry G, Smith MA, Avila J. Tau--an inhibitor of deacetylase HDAC6 function. J Neurochem. 2009 Jun;109(6):1756–1766.
Journal cover image

Published In

J Neurochem

DOI

EISSN

1471-4159

Publication Date

June 2009

Volume

109

Issue

6

Start / End Page

1756 / 1766

Location

England

Related Subject Headings

  • tau Proteins
  • Tubulin
  • Transfection
  • Postmortem Changes
  • Neurons
  • Neurology & Neurosurgery
  • Microtubule-Associated Proteins
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice