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Function of tau protein in adult newborn neurons.

Publication ,  Journal Article
Fuster-Matanzo, A; de Barreda, EG; Dawson, HN; Vitek, MP; Avila, J; Hernández, F
Published in: FEBS Lett
September 17, 2009

Levels of tau phosphorylation are high during the developmental period of intense neurite outgrowth, but decrease later. We here investigated whether tau protein plays a role in adult neurogenesis. First we demonstrate that new neurons generated in the subgranular zone express tau in a hyperphosphorylated form. Phospho-tau expression colocalized with doublecortin but not with glial fibrillary acidic protein, Ki67 or calbindin. The same was observed in the subventricular zone. Tau knockout mice did not show a significant decrease in the number of doublecortin-positive cells, although a deficit in migration was observed. These findings suggest that basal tau phosphorylation present in adult animals is in part due to neurogenesis, and from Tau knockout mice it seems that tau is involved in normal migration of new neurons.

Duke Scholars

Published In

FEBS Lett

DOI

EISSN

1873-3468

Publication Date

September 17, 2009

Volume

583

Issue

18

Start / End Page

3063 / 3068

Location

England

Related Subject Headings

  • tau Proteins
  • Phosphorylation
  • Neuropeptides
  • Neurons
  • Neurogenesis
  • Microtubule-Associated Proteins
  • Mice, Knockout
  • Mice
  • Doublecortin Domain Proteins
  • Cerebral Ventricles
 

Citation

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Fuster-Matanzo, A., de Barreda, E. G., Dawson, H. N., Vitek, M. P., Avila, J., & Hernández, F. (2009). Function of tau protein in adult newborn neurons. FEBS Lett, 583(18), 3063–3068. https://doi.org/10.1016/j.febslet.2009.08.017
Fuster-Matanzo, Almudena, Elena Gómez de Barreda, Hana N. Dawson, Michael P. Vitek, Jesús Avila, and Félix Hernández. “Function of tau protein in adult newborn neurons.FEBS Lett 583, no. 18 (September 17, 2009): 3063–68. https://doi.org/10.1016/j.febslet.2009.08.017.
Fuster-Matanzo A, de Barreda EG, Dawson HN, Vitek MP, Avila J, Hernández F. Function of tau protein in adult newborn neurons. FEBS Lett. 2009 Sep 17;583(18):3063–8.
Fuster-Matanzo, Almudena, et al. “Function of tau protein in adult newborn neurons.FEBS Lett, vol. 583, no. 18, Sept. 2009, pp. 3063–68. Pubmed, doi:10.1016/j.febslet.2009.08.017.
Fuster-Matanzo A, de Barreda EG, Dawson HN, Vitek MP, Avila J, Hernández F. Function of tau protein in adult newborn neurons. FEBS Lett. 2009 Sep 17;583(18):3063–3068.
Journal cover image

Published In

FEBS Lett

DOI

EISSN

1873-3468

Publication Date

September 17, 2009

Volume

583

Issue

18

Start / End Page

3063 / 3068

Location

England

Related Subject Headings

  • tau Proteins
  • Phosphorylation
  • Neuropeptides
  • Neurons
  • Neurogenesis
  • Microtubule-Associated Proteins
  • Mice, Knockout
  • Mice
  • Doublecortin Domain Proteins
  • Cerebral Ventricles