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Dilution of microbicide gels with vaginal fluid and semen simulants: effect on rheological properties and coating flow.

Publication ,  Journal Article
Lai, BE; Xie, YQ; Lavine, ML; Szeri, AJ; Owen, DH; Katz, DF
Published in: Journal of pharmaceutical sciences
February 2008

Microbicides are agents applied topically to the vagina to prevent HIV transmission. Microbicide products formulated as semi-solid dosage forms or "gels" coat vulnerable tissue to deliver active ingredients. Effective microbicide delivery vehicles must have appropriate rheological properties to ensure appropriate deployment in vivo. Microbicide products become diluted by fluids in the vagina after application; dilution affects vehicle rheological properties and mechanics of vaginal distribution, thus affecting efficacy. To simulate the changes that might occur after application, this study analyzed the effects of small dilutions (10-30%) with vaginal fluid and semen simulants on three semi-solid vaginal formulations: a cellulose lubricant (KY Jelly), a polyacrylic acid moisturizer (Replens), and a carrageenan prototype microbicide (Carraguard). Rheological behavior was characterized using cone-and-plate rheometry. Data were fitted to either the power-law, Carreau, or Herschel-Bulkley model. Rheological parameters from these fits were input to models of coating flow due squeezing, and the simulated area coated output from these models was used to compare the responses of the different formulations to the two diluents for varying degrees of dilution. There were differences in the responses of the three materials to dilution. Even small dilutions altered the rank order of vaginal coating rates compared to the undiluted formulations.

Duke Scholars

Published In

Journal of pharmaceutical sciences

DOI

EISSN

1520-6017

ISSN

0022-3549

Publication Date

February 2008

Volume

97

Issue

2

Start / End Page

1030 / 1038

Related Subject Headings

  • Viscosity
  • Vaginal Creams, Foams, and Jellies
  • Semen
  • Rheology
  • Pharmacology & Pharmacy
  • Male
  • Hydrogen-Ion Concentration
  • Humans
  • Gels
  • Female
 

Citation

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Lai, B. E., Xie, Y. Q., Lavine, M. L., Szeri, A. J., Owen, D. H., & Katz, D. F. (2008). Dilution of microbicide gels with vaginal fluid and semen simulants: effect on rheological properties and coating flow. Journal of Pharmaceutical Sciences, 97(2), 1030–1038. https://doi.org/10.1002/jps.21132
Lai, Bonnie E., Yao Quan Xie, Michael L. Lavine, Andrew J. Szeri, Derek H. Owen, and David F. Katz. “Dilution of microbicide gels with vaginal fluid and semen simulants: effect on rheological properties and coating flow.Journal of Pharmaceutical Sciences 97, no. 2 (February 2008): 1030–38. https://doi.org/10.1002/jps.21132.
Lai BE, Xie YQ, Lavine ML, Szeri AJ, Owen DH, Katz DF. Dilution of microbicide gels with vaginal fluid and semen simulants: effect on rheological properties and coating flow. Journal of pharmaceutical sciences. 2008 Feb;97(2):1030–8.
Lai, Bonnie E., et al. “Dilution of microbicide gels with vaginal fluid and semen simulants: effect on rheological properties and coating flow.Journal of Pharmaceutical Sciences, vol. 97, no. 2, Feb. 2008, pp. 1030–38. Epmc, doi:10.1002/jps.21132.
Lai BE, Xie YQ, Lavine ML, Szeri AJ, Owen DH, Katz DF. Dilution of microbicide gels with vaginal fluid and semen simulants: effect on rheological properties and coating flow. Journal of pharmaceutical sciences. 2008 Feb;97(2):1030–1038.
Journal cover image

Published In

Journal of pharmaceutical sciences

DOI

EISSN

1520-6017

ISSN

0022-3549

Publication Date

February 2008

Volume

97

Issue

2

Start / End Page

1030 / 1038

Related Subject Headings

  • Viscosity
  • Vaginal Creams, Foams, and Jellies
  • Semen
  • Rheology
  • Pharmacology & Pharmacy
  • Male
  • Hydrogen-Ion Concentration
  • Humans
  • Gels
  • Female