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Cardiac microimpedance measurement in two-dimensional models using multisite interstitial stimulation.

Publication ,  Journal Article
Pollard, AE; Barr, RC
Published in: American journal of physiology. Heart and circulatory physiology
May 2006

We analyzed central interstitial potential differences during multisite stimulation to assess the feasibility of using those recordings to measure cardiac microimpedances in multidimensional preparations. Because interstitial current injected and removed using electrodes with different proximities allows modulation of the portion of current crossing the membrane, we hypothesized that multisite interstitial stimulation would give rise to central interstitial potential differences that depend on intracellular and interstitial microimpedances, allowing measurement of those microimpedances. Simulations of multisite stimulation with fine and wide spacing in two-dimensional models that included dynamic membrane equations for guinea pig ventricular myocytes were performed to generate test data ( partial differentialphio). Isotropic interstitial and intracellular microimpedances were prescribed for one set of simulations, and anisotropic microimpedances with unequal ratios (intracellular to interstitial) along and across fibers were prescribed for another set of simulations. Microimpedance measurements were then obtained by making statistical comparisons between partial differentialphio values and interstitial potential differences from passive bidomain simulations (Deltaphio) in which a wide range of possible microimpedances were considered. Possible microimpedances were selected at 25% increments. After demonstrating the effectiveness of the overall method with microimpedance measurements using one-dimensional test data, we showed microimpedance measurements within 25% of prescribed values in isotropic and anisotropic models. Our findings suggest that development of microfabricated devices to implement the procedure would facilitate routine measurement as a component of cardiac electrophysiological study.

Duke Scholars

Published In

American journal of physiology. Heart and circulatory physiology

DOI

EISSN

1522-1539

ISSN

0363-6135

Publication Date

May 2006

Volume

290

Issue

5

Start / End Page

H1976 / H1987

Related Subject Headings

  • Plethysmography, Impedance
  • Muscle Cells
  • Models, Cardiovascular
  • Humans
  • Heart
  • Guinea Pigs
  • Electric Stimulation
  • Electric Impedance
  • Diagnosis, Computer-Assisted
  • Computer Simulation
 

Citation

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MLA
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Pollard, A. E., & Barr, R. C. (2006). Cardiac microimpedance measurement in two-dimensional models using multisite interstitial stimulation. American Journal of Physiology. Heart and Circulatory Physiology, 290(5), H1976–H1987. https://doi.org/10.1152/ajpheart.01180.2005
Pollard, Andrew E., and Roger C. Barr. “Cardiac microimpedance measurement in two-dimensional models using multisite interstitial stimulation.American Journal of Physiology. Heart and Circulatory Physiology 290, no. 5 (May 2006): H1976–87. https://doi.org/10.1152/ajpheart.01180.2005.
Pollard AE, Barr RC. Cardiac microimpedance measurement in two-dimensional models using multisite interstitial stimulation. American journal of physiology Heart and circulatory physiology. 2006 May;290(5):H1976–87.
Pollard, Andrew E., and Roger C. Barr. “Cardiac microimpedance measurement in two-dimensional models using multisite interstitial stimulation.American Journal of Physiology. Heart and Circulatory Physiology, vol. 290, no. 5, May 2006, pp. H1976–87. Epmc, doi:10.1152/ajpheart.01180.2005.
Pollard AE, Barr RC. Cardiac microimpedance measurement in two-dimensional models using multisite interstitial stimulation. American journal of physiology Heart and circulatory physiology. 2006 May;290(5):H1976–H1987.

Published In

American journal of physiology. Heart and circulatory physiology

DOI

EISSN

1522-1539

ISSN

0363-6135

Publication Date

May 2006

Volume

290

Issue

5

Start / End Page

H1976 / H1987

Related Subject Headings

  • Plethysmography, Impedance
  • Muscle Cells
  • Models, Cardiovascular
  • Humans
  • Heart
  • Guinea Pigs
  • Electric Stimulation
  • Electric Impedance
  • Diagnosis, Computer-Assisted
  • Computer Simulation