Skip to main content

Applications of fiber-optics-based nanosensors to drug discovery.

Publication ,  Journal Article
Vo-Dinh, T; Scaffidi, J; Gregas, M; Zhang, Y; Seewaldt, V
Published in: Expert opinion on drug discovery
August 2009

Fiber-optic nanosensors are fabricated by heating and pulling optical fibers to yield sub-micron diameter tips and have been used for in vitro analysis of individual living mammalian cells. Immobilization of bioreceptors (e.g., antibodies, peptides, DNA) selective to targeting analyte molecules of interest provides molecular specificity. Excitation light can be launched into the fiber, and the resulting evanescent field at the tip of the nanofiber can be used to excite target molecules bound to the bioreceptor molecules. The fluorescence or surface-enhanced Raman scattering produced by the analyte molecules is detected using an ultra-sensitive photodetector.This article provides an overview of the development and application of fiber-optic nanosensors for drug discovery.The nanosensors provide minimally invasive tools to probe subcellular compartments inside single living cells for health effect studies (e.g., detection of benzopyrene adducts) and medical applications (e.g., monitoring of apoptosis in cells treated with anticancer drugs).

Duke Scholars

Published In

Expert opinion on drug discovery

DOI

EISSN

1746-045X

ISSN

1746-0441

Publication Date

August 2009

Volume

4

Issue

8

Start / End Page

889 / 900

Related Subject Headings

  • Pharmacology & Pharmacy
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Vo-Dinh, T., Scaffidi, J., Gregas, M., Zhang, Y., & Seewaldt, V. (2009). Applications of fiber-optics-based nanosensors to drug discovery. Expert Opinion on Drug Discovery, 4(8), 889–900. https://doi.org/10.1517/17460440903085112
Vo-Dinh, Tuan, Jonathan Scaffidi, Molly Gregas, Yan Zhang, and Victoria Seewaldt. “Applications of fiber-optics-based nanosensors to drug discovery.Expert Opinion on Drug Discovery 4, no. 8 (August 2009): 889–900. https://doi.org/10.1517/17460440903085112.
Vo-Dinh T, Scaffidi J, Gregas M, Zhang Y, Seewaldt V. Applications of fiber-optics-based nanosensors to drug discovery. Expert opinion on drug discovery. 2009 Aug;4(8):889–900.
Vo-Dinh, Tuan, et al. “Applications of fiber-optics-based nanosensors to drug discovery.Expert Opinion on Drug Discovery, vol. 4, no. 8, Aug. 2009, pp. 889–900. Epmc, doi:10.1517/17460440903085112.
Vo-Dinh T, Scaffidi J, Gregas M, Zhang Y, Seewaldt V. Applications of fiber-optics-based nanosensors to drug discovery. Expert opinion on drug discovery. 2009 Aug;4(8):889–900.

Published In

Expert opinion on drug discovery

DOI

EISSN

1746-045X

ISSN

1746-0441

Publication Date

August 2009

Volume

4

Issue

8

Start / End Page

889 / 900

Related Subject Headings

  • Pharmacology & Pharmacy
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences