SERS-based plasmonic nanobiosensing in single living cells.
Publication
, Journal Article
Scaffidi, JP; Gregas, MK; Seewaldt, V; Vo-Dinh, T
Published in: Analytical and bioanalytical chemistry
February 2009
In this paper, we describe the development and application of a pH-sensitive plasmonics-active fiber-optic nanoprobe suitable for intracellular bioanalysis in single living human cells using surface-enhanced Raman scattering (SERS) detection. The effectiveness and usefulness of SERS-based fiber-optic nanoprobes are illustrated by measurements of intracellular pH in HMEC-15/hTERT immortalized "normal" human mammary epithelial cells and PC-3 human prostate cancer cells. The results indicate that fiber-optic nanoprobe insertion and interrogation provide a sensitive and selective means to monitor cellular microenvironments at the single cell level.
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Published In
Analytical and bioanalytical chemistry
DOI
EISSN
1618-2650
ISSN
1618-2642
Publication Date
February 2009
Volume
393
Issue
4
Start / End Page
1135 / 1141
Related Subject Headings
- Nanotechnology
- Hydrogen-Ion Concentration
- Humans
- Cell Line, Transformed
- Calibration
- Biosensing Techniques
- Analytical Chemistry
- 40 Engineering
- 34 Chemical sciences
- 31 Biological sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Scaffidi, J. P., Gregas, M. K., Seewaldt, V., & Vo-Dinh, T. (2009). SERS-based plasmonic nanobiosensing in single living cells. Analytical and Bioanalytical Chemistry, 393(4), 1135–1141. https://doi.org/10.1007/s00216-008-2521-y
Scaffidi, Jonathan P., Molly K. Gregas, Victoria Seewaldt, and Tuan Vo-Dinh. “SERS-based plasmonic nanobiosensing in single living cells.” Analytical and Bioanalytical Chemistry 393, no. 4 (February 2009): 1135–41. https://doi.org/10.1007/s00216-008-2521-y.
Scaffidi JP, Gregas MK, Seewaldt V, Vo-Dinh T. SERS-based plasmonic nanobiosensing in single living cells. Analytical and bioanalytical chemistry. 2009 Feb;393(4):1135–41.
Scaffidi, Jonathan P., et al. “SERS-based plasmonic nanobiosensing in single living cells.” Analytical and Bioanalytical Chemistry, vol. 393, no. 4, Feb. 2009, pp. 1135–41. Epmc, doi:10.1007/s00216-008-2521-y.
Scaffidi JP, Gregas MK, Seewaldt V, Vo-Dinh T. SERS-based plasmonic nanobiosensing in single living cells. Analytical and bioanalytical chemistry. 2009 Feb;393(4):1135–1141.
Published In
Analytical and bioanalytical chemistry
DOI
EISSN
1618-2650
ISSN
1618-2642
Publication Date
February 2009
Volume
393
Issue
4
Start / End Page
1135 / 1141
Related Subject Headings
- Nanotechnology
- Hydrogen-Ion Concentration
- Humans
- Cell Line, Transformed
- Calibration
- Biosensing Techniques
- Analytical Chemistry
- 40 Engineering
- 34 Chemical sciences
- 31 Biological sciences