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Results of the Cord Blood Transplantation Study (COBLT): clinical outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with hematologic malignancies.

Publication ,  Journal Article
Kurtzberg, J; Prasad, VK; Carter, SL; Wagner, JE; Baxter-Lowe, LA; Wall, D; Kapoor, N; Guinan, EC; Feig, SA; Wagner, EL; Kernan, NA ...
Published in: Blood
November 15, 2008

Outcomes of unrelated donor cord blood transplantation in 191 hematologic malignancy children (median age, 7.7 years; median weight, 25.9 kg) enrolled between 1999 and 2003 were studied (median follow-up, 27.4 months) in a prospective phase 2 multicenter trial. Human leukocyte antigen (HLA) matching at enrollment was 6/6 (n = 17), 5/6 (n = 58), 4/6 (n = 111), or 3/6 (n = 5) by low-resolution HLA-A, -B, and high-resolution (HR) DRB1. Retrospectively, 179 pairs were HLA typed by HR. The median precryopreservation total nucleated cell (TNC) dose was 5.1 x 10(7) TNC/kg (range, 1.5-23.7) with 3.9 x 10(7) TNC/kg (range, 0.8-22.8) infused. The median time to engraftment (absolute neutrophil count > 500/mm(3) and platelets 50 000/muL) was 27 and 174 days. The cumulative incidence of neutrophil engraftment by day 42 was 79.9% (95% confidence interval [CI], 75.1%-85.2%); acute grades III/IV GVHD by day 100 was 19.5% (95% CI, 13.9%-25.5%); and chronic GVHD at 2 years was 20.8% (95% CI, 14.8%-27.7%). HR matching decreased the probability of severe acute GVHD. The cumulative incidence of relapse at 2 years was 19.9% (95% CI, 14.8%-25.7%). The probabilities of 6-month and 2-year survivals were 67.4% and 49.5%. Unrelated donor cord blood transplantation from partially HLA-mismatched units can cure many children with leukemias. The study was registered at www.clinicaltrials.gov as #NCT00000603.

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Published In

Blood

DOI

EISSN

1528-0020

Publication Date

November 15, 2008

Volume

112

Issue

10

Start / End Page

4318 / 4327

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Time Factors
  • Survival Rate
  • Retrospective Studies
  • Prospective Studies
  • Platelet Count
  • Male
  • Leukocyte Count
  • Infant
  • Immunology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kurtzberg, J., Prasad, V. K., Carter, S. L., Wagner, J. E., Baxter-Lowe, L. A., Wall, D., … COBLT Steering Committee, . (2008). Results of the Cord Blood Transplantation Study (COBLT): clinical outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with hematologic malignancies. Blood, 112(10), 4318–4327. https://doi.org/10.1182/blood-2007-06-098020
Kurtzberg, Joanne, Vinod K. Prasad, Shelly L. Carter, John E. Wagner, Lee Ann Baxter-Lowe, Donna Wall, Neena Kapoor, et al. “Results of the Cord Blood Transplantation Study (COBLT): clinical outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with hematologic malignancies.Blood 112, no. 10 (November 15, 2008): 4318–27. https://doi.org/10.1182/blood-2007-06-098020.
Kurtzberg, Joanne, et al. “Results of the Cord Blood Transplantation Study (COBLT): clinical outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with hematologic malignancies.Blood, vol. 112, no. 10, Nov. 2008, pp. 4318–27. Pubmed, doi:10.1182/blood-2007-06-098020.
Kurtzberg J, Prasad VK, Carter SL, Wagner JE, Baxter-Lowe LA, Wall D, Kapoor N, Guinan EC, Feig SA, Wagner EL, Kernan NA, COBLT Steering Committee. Results of the Cord Blood Transplantation Study (COBLT): clinical outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with hematologic malignancies. Blood. 2008 Nov 15;112(10):4318–4327.

Published In

Blood

DOI

EISSN

1528-0020

Publication Date

November 15, 2008

Volume

112

Issue

10

Start / End Page

4318 / 4327

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Time Factors
  • Survival Rate
  • Retrospective Studies
  • Prospective Studies
  • Platelet Count
  • Male
  • Leukocyte Count
  • Infant
  • Immunology