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Cortical deactivation in mild cognitive impairment: high-field-strength functional MR imaging.

Publication ,  Journal Article
Petrella, JR; Wang, L; Krishnan, S; Slavin, MJ; Prince, SE; Tran, T-TT; Doraiswamy, PM
Published in: Radiology
October 2007

PURPOSE: To prospectively identify brain regions in which task-related changes in activation during a memory encoding task, measured with functional magnetic resonance (MR) imaging, correlate with degree of memory impairment across Alzheimer disease (AD), mild cognitive impairment (MCI), and elderly control subjects. MATERIALS AND METHODS: The institutional review board approved this HIPAA-compliant study, and each patient gave written informed consent. Seventy-five subjects (mean age, 72.9 years+/-7.2 [standard deviation]; 37 men, 38 women)-13 patients with mild AD, 34 individuals with amnestic MCI, and 28 healthy elderly control subjects-were imaged at 4.0 T during novel encoding (NE) and familiar encoding (FE) of face-name pairs presented within a block design for later retrieval. Blood oxygen level-dependent (BOLD) changes were assessed across the entire brain for each group. Between-subject analysis identified brain regions demonstrating a monotonic increase or decrease in activation magnitude, from control subjects to patients with MCI to patients with mild AD. BOLD response was also correlated with score on the delayed portion of the California Verbal Learning Test (CVLT). RESULTS: In controls, the task elicited positive activation (NE>FE) in the dorsolateral prefrontal, lateral parietal, and medial temporal regions, and negative activation (FE>NE) in the midline frontal and parietal regions. Along the spectrum from control subjects to patients with AD, there was decreasing activation in the medial temporal lobe (MTL), including the hippocampus and parahippocampal and fusiform gyri, and increasing activation in the posteromedial cortices (PMCs), primarily in the precuneus and posterior cingulate gyrus. Activation magnitude in the PMCs significantly (P<.001, r=-0.502) correlated with CVLT score. CONCLUSION: Compared with activation in the MTL, deactivation in the PMCs could be a more sensitive marker of early AD at functional MR imaging.

Duke Scholars

Published In

Radiology

DOI

ISSN

0033-8419

Publication Date

October 2007

Volume

245

Issue

1

Start / End Page

224 / 235

Location

United States

Related Subject Headings

  • Prospective Studies
  • Oxygen
  • Nuclear Medicine & Medical Imaging
  • Memory
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Female
  • Cognition Disorders
  • Brain
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Petrella, J. R., Wang, L., Krishnan, S., Slavin, M. J., Prince, S. E., Tran, T.-T., & Doraiswamy, P. M. (2007). Cortical deactivation in mild cognitive impairment: high-field-strength functional MR imaging. Radiology, 245(1), 224–235. https://doi.org/10.1148/radiol.2451061847
Petrella, Jeffrey R., Lihong Wang, Sriyesh Krishnan, Melissa J. Slavin, Steven E. Prince, Thanh-Thu T. Tran, and P Murali Doraiswamy. “Cortical deactivation in mild cognitive impairment: high-field-strength functional MR imaging.Radiology 245, no. 1 (October 2007): 224–35. https://doi.org/10.1148/radiol.2451061847.
Petrella JR, Wang L, Krishnan S, Slavin MJ, Prince SE, Tran T-TT, et al. Cortical deactivation in mild cognitive impairment: high-field-strength functional MR imaging. Radiology. 2007 Oct;245(1):224–35.
Petrella, Jeffrey R., et al. “Cortical deactivation in mild cognitive impairment: high-field-strength functional MR imaging.Radiology, vol. 245, no. 1, Oct. 2007, pp. 224–35. Pubmed, doi:10.1148/radiol.2451061847.
Petrella JR, Wang L, Krishnan S, Slavin MJ, Prince SE, Tran T-TT, Doraiswamy PM. Cortical deactivation in mild cognitive impairment: high-field-strength functional MR imaging. Radiology. 2007 Oct;245(1):224–235.
Journal cover image

Published In

Radiology

DOI

ISSN

0033-8419

Publication Date

October 2007

Volume

245

Issue

1

Start / End Page

224 / 235

Location

United States

Related Subject Headings

  • Prospective Studies
  • Oxygen
  • Nuclear Medicine & Medical Imaging
  • Memory
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Female
  • Cognition Disorders
  • Brain