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Longitudinal changes in central corneal thickness and their relation to glaucoma status: an 8 year follow up study.

Publication ,  Journal Article
Weizer, JS; Stinnett, SS; Herndon, LW
Published in: Br J Ophthalmol
June 2006

AIMS: To determine if central corneal thickness (CCT) changes over time and if this change relates to glaucoma progression. METHODS: 39 patients (64 eyes) with open angle glaucoma, ocular hypertension, glaucoma suspect status, or a normal eye examination were examined at two visits. CCT, age, race, sex, family history of glaucoma, presence of diabetes and systemic hypertension, diagnosis, visual acuity, spherical equivalent, intraocular pressure, vertical and horizontal cup to disc ratios, number of glaucoma medications prescribed, Advanced Glaucoma Intervention Study (AGIS) score and mean deviation of Humphrey visual fields, and interventions required were recorded. Statistical analysis used the Wilcoxon signed ranks test, linear regression, and analysis of variance. RESULTS: Between the two visits (mean 8.2 years apart), mean CCT decreased by 17 mum in right eyes (p<0.002) and by 23 mum in left eyes (p<0.001). This decrease was greater in right eyes of patients with primary open angle glaucoma than in normals (p = 0.041). There was no significant association between change in CCT and other examination parameters. Change in CCT was not associated with topical carbonic anhydrase inhibitor use. CONCLUSION: In this longitudinal study, CCT decreased over time, but this may not be related to glaucoma progression.

Duke Scholars

Published In

Br J Ophthalmol

DOI

ISSN

0007-1161

Publication Date

June 2006

Volume

90

Issue

6

Start / End Page

732 / 736

Location

England

Related Subject Headings

  • Visual Fields
  • Visual Acuity
  • Ophthalmology & Optometry
  • Ocular Hypertension
  • Middle Aged
  • Male
  • Humans
  • Glaucoma, Open-Angle
  • Glaucoma
  • Follow-Up Studies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Weizer, J. S., Stinnett, S. S., & Herndon, L. W. (2006). Longitudinal changes in central corneal thickness and their relation to glaucoma status: an 8 year follow up study. Br J Ophthalmol, 90(6), 732–736. https://doi.org/10.1136/bjo.2005.087155
Weizer, J. S., S. S. Stinnett, and L. W. Herndon. “Longitudinal changes in central corneal thickness and their relation to glaucoma status: an 8 year follow up study.Br J Ophthalmol 90, no. 6 (June 2006): 732–36. https://doi.org/10.1136/bjo.2005.087155.
Weizer JS, Stinnett SS, Herndon LW. Longitudinal changes in central corneal thickness and their relation to glaucoma status: an 8 year follow up study. Br J Ophthalmol. 2006 Jun;90(6):732–6.
Weizer, J. S., et al. “Longitudinal changes in central corneal thickness and their relation to glaucoma status: an 8 year follow up study.Br J Ophthalmol, vol. 90, no. 6, June 2006, pp. 732–36. Pubmed, doi:10.1136/bjo.2005.087155.
Weizer JS, Stinnett SS, Herndon LW. Longitudinal changes in central corneal thickness and their relation to glaucoma status: an 8 year follow up study. Br J Ophthalmol. 2006 Jun;90(6):732–736.

Published In

Br J Ophthalmol

DOI

ISSN

0007-1161

Publication Date

June 2006

Volume

90

Issue

6

Start / End Page

732 / 736

Location

England

Related Subject Headings

  • Visual Fields
  • Visual Acuity
  • Ophthalmology & Optometry
  • Ocular Hypertension
  • Middle Aged
  • Male
  • Humans
  • Glaucoma, Open-Angle
  • Glaucoma
  • Follow-Up Studies