Skip to main content
Journal cover image

Invasive non-Typhi Salmonella disease in Africa.

Publication ,  Journal Article
Morpeth, SC; Ramadhani, HO; Crump, JA
Published in: Clin Infect Dis
August 15, 2009

Invasive non-Typhi Salmonella is endemic to sub-Saharan Africa, where it is a leading cause of bloodstream infection. Some host risk factors have been established, but little is known about environmental reservoirs and predominant modes of transmission, so prevention strategies are underdeveloped. Although foodborne transmission from animals to humans predominates in high-income countries, it has been postulated that transmission between humans, both within and outside health care facilities, may be important in sub-Saharan Africa. Antimicrobial resistance to ampicillin, trimethoprim-sulfamethoxazole, and chloramphenicol is common among non-Typhi Salmonella strains; therefore, wider use of alternative agents may be warranted for empirical therapy. Development of vaccines targeting the leading invasive non-Typhi Salmonella serotypes Typhimurium and Enteritidis is warranted. The clinical presentation of non-Typhi Salmonella bacteremia is nonspecific and, in the absence of blood culture, may be confused with other febrile illnesses, such as malaria. Much work remains to be done to understand and control invasive non-Typhi Salmonella disease in sub-Saharan Africa.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Clin Infect Dis

DOI

EISSN

1537-6591

Publication Date

August 15, 2009

Volume

49

Issue

4

Start / End Page

606 / 611

Location

United States

Related Subject Headings

  • Salmonella Infections, Animal
  • Salmonella Infections
  • Salmonella Food Poisoning
  • Salmonella
  • Microbiology
  • Humans
  • Drug Resistance, Bacterial
  • Anti-Bacterial Agents
  • Animals
  • Africa South of the Sahara
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Morpeth, S. C., Ramadhani, H. O., & Crump, J. A. (2009). Invasive non-Typhi Salmonella disease in Africa. Clin Infect Dis, 49(4), 606–611. https://doi.org/10.1086/603553
Morpeth, Susan C., Habib O. Ramadhani, and John A. Crump. “Invasive non-Typhi Salmonella disease in Africa.Clin Infect Dis 49, no. 4 (August 15, 2009): 606–11. https://doi.org/10.1086/603553.
Morpeth SC, Ramadhani HO, Crump JA. Invasive non-Typhi Salmonella disease in Africa. Clin Infect Dis. 2009 Aug 15;49(4):606–11.
Morpeth, Susan C., et al. “Invasive non-Typhi Salmonella disease in Africa.Clin Infect Dis, vol. 49, no. 4, Aug. 2009, pp. 606–11. Pubmed, doi:10.1086/603553.
Morpeth SC, Ramadhani HO, Crump JA. Invasive non-Typhi Salmonella disease in Africa. Clin Infect Dis. 2009 Aug 15;49(4):606–611.
Journal cover image

Published In

Clin Infect Dis

DOI

EISSN

1537-6591

Publication Date

August 15, 2009

Volume

49

Issue

4

Start / End Page

606 / 611

Location

United States

Related Subject Headings

  • Salmonella Infections, Animal
  • Salmonella Infections
  • Salmonella Food Poisoning
  • Salmonella
  • Microbiology
  • Humans
  • Drug Resistance, Bacterial
  • Anti-Bacterial Agents
  • Animals
  • Africa South of the Sahara