The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia.
Publication
, Journal Article
Pantaleo, G; Demarest, JF; Schacker, T; Vaccarezza, M; Cohen, OJ; Daucher, M; Graziosi, C; Schnittman, SS; Quinn, TC; Shaw, GM; Perrin, L ...
Published in: Proc Natl Acad Sci U S A
January 7, 1997
Following infection of the host with a virus, the delicate balance between virus replication/spread and the immune response to the virus determines the outcome of infection, i.e., persistence versus elimination of the virus. It is unclear, however, what relative roles immunologic and virologic factors play during primary viral infection in determining the subsequent clinical outcome. By studying a cohort of subjects with primary HIV infection, it has been demonstrated that qualitative differences in the primary immune response to HIV, but not quantitative differences in the initial levels of viremia are associated with different clinical outcomes.
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Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
January 7, 1997
Volume
94
Issue
1
Start / End Page
254 / 258
Location
United States
Related Subject Headings
- Viremia
- Receptors, Antigen, T-Cell, alpha-beta
- RNA, Viral
- Leukocytes, Mononuclear
- Humans
- HIV Infections
- Forecasting
- Disease Progression
- Cohort Studies
- Chronic Disease
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Pantaleo, G., Demarest, J. F., Schacker, T., Vaccarezza, M., Cohen, O. J., Daucher, M., … Fauci, A. S. (1997). The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia. Proc Natl Acad Sci U S A, 94(1), 254–258. https://doi.org/10.1073/pnas.94.1.254
Pantaleo, G., J. F. Demarest, T. Schacker, M. Vaccarezza, O. J. Cohen, M. Daucher, C. Graziosi, et al. “The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia.” Proc Natl Acad Sci U S A 94, no. 1 (January 7, 1997): 254–58. https://doi.org/10.1073/pnas.94.1.254.
Pantaleo G, Demarest JF, Schacker T, Vaccarezza M, Cohen OJ, Daucher M, et al. The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia. Proc Natl Acad Sci U S A. 1997 Jan 7;94(1):254–8.
Pantaleo, G., et al. “The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia.” Proc Natl Acad Sci U S A, vol. 94, no. 1, Jan. 1997, pp. 254–58. Pubmed, doi:10.1073/pnas.94.1.254.
Pantaleo G, Demarest JF, Schacker T, Vaccarezza M, Cohen OJ, Daucher M, Graziosi C, Schnittman SS, Quinn TC, Shaw GM, Perrin L, Tambussi G, Lazzarin A, Sekaly RP, Soudeyns H, Corey L, Fauci AS. The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia. Proc Natl Acad Sci U S A. 1997 Jan 7;94(1):254–258.
Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
January 7, 1997
Volume
94
Issue
1
Start / End Page
254 / 258
Location
United States
Related Subject Headings
- Viremia
- Receptors, Antigen, T-Cell, alpha-beta
- RNA, Viral
- Leukocytes, Mononuclear
- Humans
- HIV Infections
- Forecasting
- Disease Progression
- Cohort Studies
- Chronic Disease