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'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR.

Publication ,  Journal Article
Park, J-H; Adoro, S; Lucas, PJ; Sarafova, SD; Alag, AS; Doan, LL; Erman, B; Liu, X; Ellmeier, W; Bosselut, R; Feigenbaum, L; Singer, A
Published in: Nat Immunol
October 2007

T cell immunity requires the long-term survival of T cells that are capable of recognizing self antigens but are not overtly autoreactive. How this balance is achieved remains incompletely understood. Here we identify a homeostatic mechanism that transcriptionally tailors CD8 coreceptor expression in individual CD8+ T cells to the self-specificity of their clonotypic T cell receptor (TCR). 'Coreceptor tuning' results from interplay between cytokine and TCR signals, such that signals from interleukin 7 and other common gamma-chain cytokines transcriptionally increase CD8 expression and thereby promote TCR engagement of self ligands, whereas TCR signals impair common gamma-chain cytokine signaling and thereby decrease CD8 expression. This dynamic interplay induces individual CD8+ T cells to express CD8 in quantities appropriate for the self-specificity of their TCR, promoting the engagement of self ligands, yet avoiding autoreactivity.

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Published In

Nat Immunol

DOI

ISSN

1529-2908

Publication Date

October 2007

Volume

8

Issue

10

Start / End Page

1049 / 1059

Location

United States

Related Subject Headings

  • Up-Regulation
  • Transcription, Genetic
  • Signal Transduction
  • Receptors, Antigen, T-Cell
  • Mice
  • Interleukin-7
  • Immunology
  • Humans
  • Homeostasis
  • Enhancer Elements, Genetic
 

Citation

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Park, J.-H., Adoro, S., Lucas, P. J., Sarafova, S. D., Alag, A. S., Doan, L. L., … Singer, A. (2007). 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR. Nat Immunol, 8(10), 1049–1059. https://doi.org/10.1038/ni1512
Park, Jung-Hyun, Stanley Adoro, Philip J. Lucas, Sophia D. Sarafova, Amala S. Alag, Loretta L. Doan, Batu Erman, et al. “'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR.Nat Immunol 8, no. 10 (October 2007): 1049–59. https://doi.org/10.1038/ni1512.
Park J-H, Adoro S, Lucas PJ, Sarafova SD, Alag AS, Doan LL, et al. 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR. Nat Immunol. 2007 Oct;8(10):1049–59.
Park, Jung-Hyun, et al. “'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR.Nat Immunol, vol. 8, no. 10, Oct. 2007, pp. 1049–59. Pubmed, doi:10.1038/ni1512.
Park J-H, Adoro S, Lucas PJ, Sarafova SD, Alag AS, Doan LL, Erman B, Liu X, Ellmeier W, Bosselut R, Feigenbaum L, Singer A. 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR. Nat Immunol. 2007 Oct;8(10):1049–1059.

Published In

Nat Immunol

DOI

ISSN

1529-2908

Publication Date

October 2007

Volume

8

Issue

10

Start / End Page

1049 / 1059

Location

United States

Related Subject Headings

  • Up-Regulation
  • Transcription, Genetic
  • Signal Transduction
  • Receptors, Antigen, T-Cell
  • Mice
  • Interleukin-7
  • Immunology
  • Humans
  • Homeostasis
  • Enhancer Elements, Genetic