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Mechanisms of Gene-Environment Interaction Effects in the Development of Conduct Disorder.

Publication ,  Journal Article
Dodge, KA
Published in: Perspectives on psychological science : a journal of the Association for Psychological Science
July 2009

The gene-environment interaction effect in the development of conduct disorder is one of the most important discoveries of the past decade, but the mechanisms through which this effect operates remain elusive. I propose a model of these processes that focuses on the individual's response to a threatening stimulus in ongoing social interaction. The individual's response coordinates three interrelated systems: neural, autonomic, and information-processing. In each system, adaptive, evolutionarily selected response patterns characterize normal responding, but in psychopathology these patterns have gone awry. Antecedents of individual differences in these response patterns arise from genetic polymorphisms, adverse environmental experiences early in life, and their interaction. Programs of research are proposed to test hypotheses in the model through longitudinal, experimental, and clinical intervention methods. This model can serve as a template for inquiry in other forms of developmental psychopathology.

Duke Scholars

Published In

Perspectives on psychological science : a journal of the Association for Psychological Science

DOI

EISSN

1745-6924

ISSN

1745-6916

Publication Date

July 2009

Volume

4

Issue

4

Start / End Page

408 / 414

Related Subject Headings

  • Social Psychology
  • 52 Psychology
  • 1702 Cognitive Sciences
  • 1701 Psychology
 

Citation

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ICMJE
MLA
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Dodge, K. A. (2009). Mechanisms of Gene-Environment Interaction Effects in the Development of Conduct Disorder. Perspectives on Psychological Science : A Journal of the Association for Psychological Science, 4(4), 408–414. https://doi.org/10.1111/j.1745-6924.2009.01147.x
Dodge, Kenneth A. “Mechanisms of Gene-Environment Interaction Effects in the Development of Conduct Disorder.Perspectives on Psychological Science : A Journal of the Association for Psychological Science 4, no. 4 (July 2009): 408–14. https://doi.org/10.1111/j.1745-6924.2009.01147.x.
Dodge KA. Mechanisms of Gene-Environment Interaction Effects in the Development of Conduct Disorder. Perspectives on psychological science : a journal of the Association for Psychological Science. 2009 Jul;4(4):408–14.
Dodge, Kenneth A. “Mechanisms of Gene-Environment Interaction Effects in the Development of Conduct Disorder.Perspectives on Psychological Science : A Journal of the Association for Psychological Science, vol. 4, no. 4, July 2009, pp. 408–14. Epmc, doi:10.1111/j.1745-6924.2009.01147.x.
Dodge KA. Mechanisms of Gene-Environment Interaction Effects in the Development of Conduct Disorder. Perspectives on psychological science : a journal of the Association for Psychological Science. 2009 Jul;4(4):408–414.
Journal cover image

Published In

Perspectives on psychological science : a journal of the Association for Psychological Science

DOI

EISSN

1745-6924

ISSN

1745-6916

Publication Date

July 2009

Volume

4

Issue

4

Start / End Page

408 / 414

Related Subject Headings

  • Social Psychology
  • 52 Psychology
  • 1702 Cognitive Sciences
  • 1701 Psychology