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Applications of the repeatability of quantitative imaging biomarkers: a review of statistical analysis of repeat data sets.

Publication ,  Journal Article
Barnhart, HX; Barboriak, DP
Published in: Transl Oncol
December 2009

Repeat imaging data sets performed on patients with cancer are becoming publicly available. The potential utility of these data sets for addressing important questions in imaging biomarker development is vast. In particular, these data sets may be useful to help characterize the variability of quantitative parameters derived from imaging. This article reviews statistical analysis that may be performed to use results of repeat imaging to 1) calculate the level of change in parameter value that may be seen in individual patients to confidently characterize that patient as showing true parameter change, 2) calculate the level of change in parameters value that may be seen in individual patients to confidently categorize that patient as showing true lack of parameter change, 3) determine if different imaging devices are interchangeable from the standpoint of repeatability, and 4) estimate the numbers of patients needed to precisely calculate repeatability. In addition, we recommend a set of statistical parameters that should be reported when the repeatability of continuous parameters is studied.

Duke Scholars

Published In

Transl Oncol

DOI

EISSN

1936-5233

Publication Date

December 2009

Volume

2

Issue

4

Start / End Page

231 / 235

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
  • 1112 Oncology and Carcinogenesis
  • 1103 Clinical Sciences
  • 0601 Biochemistry and Cell Biology
 

Citation

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ICMJE
MLA
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Barnhart, H. X., & Barboriak, D. P. (2009). Applications of the repeatability of quantitative imaging biomarkers: a review of statistical analysis of repeat data sets. Transl Oncol, 2(4), 231–235. https://doi.org/10.1593/tlo.09268
Barnhart, Huiman X., and Daniel P. Barboriak. “Applications of the repeatability of quantitative imaging biomarkers: a review of statistical analysis of repeat data sets.Transl Oncol 2, no. 4 (December 2009): 231–35. https://doi.org/10.1593/tlo.09268.
Barnhart, Huiman X., and Daniel P. Barboriak. “Applications of the repeatability of quantitative imaging biomarkers: a review of statistical analysis of repeat data sets.Transl Oncol, vol. 2, no. 4, Dec. 2009, pp. 231–35. Pubmed, doi:10.1593/tlo.09268.
Journal cover image

Published In

Transl Oncol

DOI

EISSN

1936-5233

Publication Date

December 2009

Volume

2

Issue

4

Start / End Page

231 / 235

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
  • 1112 Oncology and Carcinogenesis
  • 1103 Clinical Sciences
  • 0601 Biochemistry and Cell Biology