The genetics of inbreeding depression.
Publication
, Journal Article
Charlesworth, D; Willis, JH
Published in: Nature reviews. Genetics
November 2009
Inbreeding depression - the reduced survival and fertility of offspring of related individuals - occurs in wild animal and plant populations as well as in humans, indicating that genetic variation in fitness traits exists in natural populations. Inbreeding depression is important in the evolution of outcrossing mating systems and, because intercrossing inbred strains improves yield (heterosis), which is important in crop breeding, the genetic basis of these effects has been debated since the early twentieth century. Classical genetic studies and modern molecular evolutionary approaches now suggest that inbreeding depression and heterosis are predominantly caused by the presence of recessive deleterious mutations in populations.
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Published In
Nature reviews. Genetics
DOI
EISSN
1471-0064
ISSN
1471-0056
Publication Date
November 2009
Volume
10
Issue
11
Start / End Page
783 / 796
Related Subject Headings
- Mutation
- Inbreeding
- Humans
- Genes, Recessive
- Developmental Biology
- Consanguinity
- Animals
- 3105 Genetics
- 3101 Biochemistry and cell biology
- 0607 Plant Biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Charlesworth, D., & Willis, J. H. (2009). The genetics of inbreeding depression. Nature Reviews. Genetics, 10(11), 783–796. https://doi.org/10.1038/nrg2664
Charlesworth, Deborah, and John H. Willis. “The genetics of inbreeding depression.” Nature Reviews. Genetics 10, no. 11 (November 2009): 783–96. https://doi.org/10.1038/nrg2664.
Charlesworth D, Willis JH. The genetics of inbreeding depression. Nature reviews Genetics. 2009 Nov;10(11):783–96.
Charlesworth, Deborah, and John H. Willis. “The genetics of inbreeding depression.” Nature Reviews. Genetics, vol. 10, no. 11, Nov. 2009, pp. 783–96. Epmc, doi:10.1038/nrg2664.
Charlesworth D, Willis JH. The genetics of inbreeding depression. Nature reviews Genetics. 2009 Nov;10(11):783–796.
Published In
Nature reviews. Genetics
DOI
EISSN
1471-0064
ISSN
1471-0056
Publication Date
November 2009
Volume
10
Issue
11
Start / End Page
783 / 796
Related Subject Headings
- Mutation
- Inbreeding
- Humans
- Genes, Recessive
- Developmental Biology
- Consanguinity
- Animals
- 3105 Genetics
- 3101 Biochemistry and cell biology
- 0607 Plant Biology