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A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsiveness.

Publication ,  Journal Article
Moeller, BJ; Batinic-Haberle, I; Spasojevic, I; Rabbani, ZN; Anscher, MS; Vujaskovic, Z; Dewhirst, MW
Published in: Int J Radiat Oncol Biol Phys
October 1, 2005

PURPOSE: To determine the effect of the superoxide dismutase mimetic Mn(III) tetrakis(N-ethylpyridinium-2-yl)porphyrin (MnTE-2-PyP(5+)) on tumor radioresponsiveness. METHODS AND MATERIALS: Various rodent tumor (4T1, R3230, B16) and endothelial (SVEC) cell lines were exposed to MnTE-2-PyP(5+) and assayed for viability and radiosensitivity in vitro. Next, tumors were treated with radiation and MnTE-2-PyP(5+)in vivo, and the effects on tumor growth and vascularity were monitored. RESULTS: In vitro, MnTE-2-PyP(5+) was not significantly cytotoxic. However, at concentrations as low as 2 mumol/L it caused 100% inhibition of secretion by tumor cells of cytokines protective of irradiated endothelial cells. In vivo, combined treatment with radiation and MnTE-2-PyP(5+) achieved synergistic tumor devascularization, reducing vascular density by 78.7% within 72 h of radiotherapy (p < 0.05 vs. radiation or drug alone). Co-treatment of tumors also resulted in synergistic antitumor effects, extending tumor growth delay by 9 days (p < 0.01). CONCLUSIONS: These studies support the conclusion that MnTE-2-PyP(5+), which has been shown to protect normal tissues from radiation injury, can also improve tumor control through augmenting radiation-induced damage to the tumor vasculature.

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Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

October 1, 2005

Volume

63

Issue

2

Start / End Page

545 / 552

Location

United States

Related Subject Headings

  • Rodentia
  • Rats, Inbred F344
  • Rats
  • Radiation-Sensitizing Agents
  • Radiation-Protective Agents
  • Radiation Tolerance
  • Oncology & Carcinogenesis
  • Neoplasms
  • Mice, Inbred BALB C
  • Mice
 

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Moeller, B. J., Batinic-Haberle, I., Spasojevic, I., Rabbani, Z. N., Anscher, M. S., Vujaskovic, Z., & Dewhirst, M. W. (2005). A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsiveness. Int J Radiat Oncol Biol Phys, 63(2), 545–552. https://doi.org/10.1016/j.ijrobp.2005.05.026
Moeller, Benjamin J., Ines Batinic-Haberle, Ivan Spasojevic, Zahid N. Rabbani, Mitchell S. Anscher, Zeljko Vujaskovic, and Mark W. Dewhirst. “A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsiveness.Int J Radiat Oncol Biol Phys 63, no. 2 (October 1, 2005): 545–52. https://doi.org/10.1016/j.ijrobp.2005.05.026.
Moeller BJ, Batinic-Haberle I, Spasojevic I, Rabbani ZN, Anscher MS, Vujaskovic Z, et al. A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsiveness. Int J Radiat Oncol Biol Phys. 2005 Oct 1;63(2):545–52.
Moeller, Benjamin J., et al. “A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsiveness.Int J Radiat Oncol Biol Phys, vol. 63, no. 2, Oct. 2005, pp. 545–52. Pubmed, doi:10.1016/j.ijrobp.2005.05.026.
Moeller BJ, Batinic-Haberle I, Spasojevic I, Rabbani ZN, Anscher MS, Vujaskovic Z, Dewhirst MW. A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsiveness. Int J Radiat Oncol Biol Phys. 2005 Oct 1;63(2):545–552.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

October 1, 2005

Volume

63

Issue

2

Start / End Page

545 / 552

Location

United States

Related Subject Headings

  • Rodentia
  • Rats, Inbred F344
  • Rats
  • Radiation-Sensitizing Agents
  • Radiation-Protective Agents
  • Radiation Tolerance
  • Oncology & Carcinogenesis
  • Neoplasms
  • Mice, Inbred BALB C
  • Mice