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Synergistic effects of hyperoxic gas breathing and reduced oxygen consumption on tumor oxygenation: a theoretical model.

Publication ,  Journal Article
Secomb, TW; Hsu, R; Dewhirst, MW
Published in: Int J Radiat Oncol Biol Phys
June 1, 2004

PURPOSE: To simulate effects of reduced oxygen consumption combined with hyperoxic gas breathing on tumor oxygenation, and to test for synergistic effects. METHODS AND MATERIALS: Diffusive oxygen transport was simulated for a small region of tumor containing a three-dimensional network of microvessels whose geometry was derived from in vivo observations. Changes in tissue partial pressure of oxygen (PO(2)) and hypoxic fraction (PO(2) < 5 mm Hg) resulting from a 30% reduction in oxygen consumption rate or breathing 100% oxygen were estimated. The synergistic effect was defined as the change in PO(2) with the two treatments combined, minus the sum of the changes with the separate treatments. RESULTS: Predicted hypoxic fractions were 37% in the control state, 11% with reduced consumption, 23% with oxygen breathing alone, and 0% with the combined treatment. The synergistic effect was about 4 mm Hg at tissue points with very low initial PO(2) levels and decreased as initial PO(2) increased. CONCLUSIONS: Reduction of oxygen consumption via the Crabtree effect, by administration of glucose, has been proposed as a means to improve tumor oxygenation during radiation treatment. The results support previous experimental studies showing that this approach is more effective when combined with breathing of hyperoxic gases.

Duke Scholars

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

June 1, 2004

Volume

59

Issue

2

Start / End Page

572 / 578

Location

United States

Related Subject Headings

  • Regional Blood Flow
  • Rats
  • Partial Pressure
  • Oxygen Consumption
  • Oxygen
  • Oncology & Carcinogenesis
  • Neoplasms
  • Models, Biological
  • Cell Respiration
  • Cell Hypoxia
 

Citation

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Chicago
ICMJE
MLA
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Secomb, T. W., Hsu, R., & Dewhirst, M. W. (2004). Synergistic effects of hyperoxic gas breathing and reduced oxygen consumption on tumor oxygenation: a theoretical model. Int J Radiat Oncol Biol Phys, 59(2), 572–578. https://doi.org/10.1016/j.ijrobp.2004.01.039
Secomb, Timothy W., Richard Hsu, and Mark W. Dewhirst. “Synergistic effects of hyperoxic gas breathing and reduced oxygen consumption on tumor oxygenation: a theoretical model.Int J Radiat Oncol Biol Phys 59, no. 2 (June 1, 2004): 572–78. https://doi.org/10.1016/j.ijrobp.2004.01.039.
Secomb TW, Hsu R, Dewhirst MW. Synergistic effects of hyperoxic gas breathing and reduced oxygen consumption on tumor oxygenation: a theoretical model. Int J Radiat Oncol Biol Phys. 2004 Jun 1;59(2):572–8.
Secomb, Timothy W., et al. “Synergistic effects of hyperoxic gas breathing and reduced oxygen consumption on tumor oxygenation: a theoretical model.Int J Radiat Oncol Biol Phys, vol. 59, no. 2, June 2004, pp. 572–78. Pubmed, doi:10.1016/j.ijrobp.2004.01.039.
Secomb TW, Hsu R, Dewhirst MW. Synergistic effects of hyperoxic gas breathing and reduced oxygen consumption on tumor oxygenation: a theoretical model. Int J Radiat Oncol Biol Phys. 2004 Jun 1;59(2):572–578.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

June 1, 2004

Volume

59

Issue

2

Start / End Page

572 / 578

Location

United States

Related Subject Headings

  • Regional Blood Flow
  • Rats
  • Partial Pressure
  • Oxygen Consumption
  • Oxygen
  • Oncology & Carcinogenesis
  • Neoplasms
  • Models, Biological
  • Cell Respiration
  • Cell Hypoxia