Skip to main content
Journal cover image

Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury.

Publication ,  Journal Article
Rabbani, ZN; Batinic-Haberle, I; Anscher, MS; Huang, J; Day, BJ; Alexander, E; Dewhirst, MW; Vujaskovic, Z
Published in: Int J Radiat Oncol Biol Phys
February 1, 2007

PURPOSE: To determine whether administration of a catalytic antioxidant, Mn(III) tetrakis(N,N'-diethylimidazolium-2-yl) porphyrin, AEOL 10150, with superoxide dismutase (SOD) mimetic properties, reduces the severity of radiation-induced injury to the lung from single-dose irradiation (RT) of 28 Gy. METHODS AND MATERIALS: Rats were randomly divided into four different dose groups (0, 1, 10, and 30 mg/kg/day of AEOL 10150), receiving either short-term (1 week) or long-term (10 weeks) drug administration via osmotic pumps. Rats received single-dose irradiation (RT) of 28 Gy to the right hemithorax. Breathing rates, body weights, blood samples, histopathology, and immunohistochemistry were used to assess lung damage. RESULTS: There was no significant difference in any of the study endpoints between the irradiated controls and the three groups receiving RT and short-term administration of AEOL 10150. For the long-term administration, functional determinants of lung damage 20 weeks postradiation were significantly worse for RT + phosphate-buffered saline (PBS) and RT + 1 mg/kg/day of AEOL 10150 as compared with the irradiated groups treated with higher doses of AEOL 10150 (10 or 30 mg/kg/day). Lung histology at 20 weeks revealed a significant decrease in structural damage and collagen deposition in rats receiving 10 or 30 mg/kg/day after radiation in comparison to the RT + PBS and 1 mg/kg/day groups. Immunohistochemistry demonstrated a significant reduction in macrophage accumulation, oxidative stress, and hypoxia in rats receiving AEOL 10150 (10 or 30 mg/kg/day) after lung irradiation compared with the RT + PBS and 1 mg/kg/day groups. CONCLUSIONS: The chronic administration of a novel catalytic antioxidant, AEOL 10150, demonstrates a significant protective effect from radiation-induced lung injury. AEOL 10150 has its primary impact on the cascade of events after irradiation, and adding the drug before irradiation and its short-term administration have no significant additional benefits.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

February 1, 2007

Volume

67

Issue

2

Start / End Page

573 / 580

Location

United States

Related Subject Headings

  • Rats, Inbred F344
  • Rats
  • Random Allocation
  • Radiation-Protective Agents
  • Radiation Injuries, Experimental
  • Radiation Injuries
  • Oncology & Carcinogenesis
  • Metalloporphyrins
  • Macrophages
  • Lung
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Rabbani, Z. N., Batinic-Haberle, I., Anscher, M. S., Huang, J., Day, B. J., Alexander, E., … Vujaskovic, Z. (2007). Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury. Int J Radiat Oncol Biol Phys, 67(2), 573–580. https://doi.org/10.1016/j.ijrobp.2006.09.053
Rabbani, Zahid N., Ines Batinic-Haberle, Mitchell S. Anscher, Jie Huang, Brian J. Day, Elaine Alexander, Mark W. Dewhirst, and Zeljko Vujaskovic. “Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury.Int J Radiat Oncol Biol Phys 67, no. 2 (February 1, 2007): 573–80. https://doi.org/10.1016/j.ijrobp.2006.09.053.
Rabbani ZN, Batinic-Haberle I, Anscher MS, Huang J, Day BJ, Alexander E, et al. Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury. Int J Radiat Oncol Biol Phys. 2007 Feb 1;67(2):573–80.
Rabbani, Zahid N., et al. “Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury.Int J Radiat Oncol Biol Phys, vol. 67, no. 2, Feb. 2007, pp. 573–80. Pubmed, doi:10.1016/j.ijrobp.2006.09.053.
Rabbani ZN, Batinic-Haberle I, Anscher MS, Huang J, Day BJ, Alexander E, Dewhirst MW, Vujaskovic Z. Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury. Int J Radiat Oncol Biol Phys. 2007 Feb 1;67(2):573–580.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

February 1, 2007

Volume

67

Issue

2

Start / End Page

573 / 580

Location

United States

Related Subject Headings

  • Rats, Inbred F344
  • Rats
  • Random Allocation
  • Radiation-Protective Agents
  • Radiation Injuries, Experimental
  • Radiation Injuries
  • Oncology & Carcinogenesis
  • Metalloporphyrins
  • Macrophages
  • Lung