Exploring the role of HIF-1 in early angiogenesis and response to radiotherapy.
Publication
, Journal Article
Dewhirst, MW; Cao, Y; Li, CY; Moeller, B
Published in: Radiother Oncol
June 2007
The objective of this review is to examine the role that HIF-1 plays in the initiation of angiogenesis and in radiotherapy response. Although these two phenomena may at first seem unrelated, there are parallelisms to be drawn associated with the importance of reactive oxygen species in controlling the transcriptional activity of HIF-1, independently of its main driving force, hypoxia. Knowledge of the mechanisms underlying the control of HIF-1 leads to rationale for its inhibition in a range of clinical scenarios.
Duke Scholars
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Published In
Radiother Oncol
DOI
ISSN
0167-8140
Publication Date
June 2007
Volume
83
Issue
3
Start / End Page
249 / 255
Location
Ireland
Related Subject Headings
- Radiotherapy
- Oncology & Carcinogenesis
- Neovascularization, Pathologic
- Hypoxia-Inducible Factor 1
- Hypoxia
- Humans
- 5105 Medical and biological physics
- 3211 Oncology and carcinogenesis
- 3202 Clinical sciences
- 1112 Oncology and Carcinogenesis
Citation
APA
Chicago
ICMJE
MLA
NLM
Dewhirst, M. W., Cao, Y., Li, C. Y., & Moeller, B. (2007). Exploring the role of HIF-1 in early angiogenesis and response to radiotherapy. Radiother Oncol, 83(3), 249–255. https://doi.org/10.1016/j.radonc.2007.05.016
Dewhirst, Mark W., Yiting Cao, Chuan Yuan Li, and Benjamin Moeller. “Exploring the role of HIF-1 in early angiogenesis and response to radiotherapy.” Radiother Oncol 83, no. 3 (June 2007): 249–55. https://doi.org/10.1016/j.radonc.2007.05.016.
Dewhirst MW, Cao Y, Li CY, Moeller B. Exploring the role of HIF-1 in early angiogenesis and response to radiotherapy. Radiother Oncol. 2007 Jun;83(3):249–55.
Dewhirst, Mark W., et al. “Exploring the role of HIF-1 in early angiogenesis and response to radiotherapy.” Radiother Oncol, vol. 83, no. 3, June 2007, pp. 249–55. Pubmed, doi:10.1016/j.radonc.2007.05.016.
Dewhirst MW, Cao Y, Li CY, Moeller B. Exploring the role of HIF-1 in early angiogenesis and response to radiotherapy. Radiother Oncol. 2007 Jun;83(3):249–255.
Published In
Radiother Oncol
DOI
ISSN
0167-8140
Publication Date
June 2007
Volume
83
Issue
3
Start / End Page
249 / 255
Location
Ireland
Related Subject Headings
- Radiotherapy
- Oncology & Carcinogenesis
- Neovascularization, Pathologic
- Hypoxia-Inducible Factor 1
- Hypoxia
- Humans
- 5105 Medical and biological physics
- 3211 Oncology and carcinogenesis
- 3202 Clinical sciences
- 1112 Oncology and Carcinogenesis