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Exploring the role of HIF-1 in early angiogenesis and response to radiotherapy.

Publication ,  Journal Article
Dewhirst, MW; Cao, Y; Li, CY; Moeller, B
Published in: Radiother Oncol
June 2007

The objective of this review is to examine the role that HIF-1 plays in the initiation of angiogenesis and in radiotherapy response. Although these two phenomena may at first seem unrelated, there are parallelisms to be drawn associated with the importance of reactive oxygen species in controlling the transcriptional activity of HIF-1, independently of its main driving force, hypoxia. Knowledge of the mechanisms underlying the control of HIF-1 leads to rationale for its inhibition in a range of clinical scenarios.

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Published In

Radiother Oncol

DOI

ISSN

0167-8140

Publication Date

June 2007

Volume

83

Issue

3

Start / End Page

249 / 255

Location

Ireland

Related Subject Headings

  • Radiotherapy
  • Oncology & Carcinogenesis
  • Neovascularization, Pathologic
  • Hypoxia-Inducible Factor 1
  • Hypoxia
  • Humans
  • 5105 Medical and biological physics
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences
  • 1112 Oncology and Carcinogenesis
 

Citation

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MLA
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Dewhirst, M. W., Cao, Y., Li, C. Y., & Moeller, B. (2007). Exploring the role of HIF-1 in early angiogenesis and response to radiotherapy. Radiother Oncol, 83(3), 249–255. https://doi.org/10.1016/j.radonc.2007.05.016
Dewhirst, Mark W., Yiting Cao, Chuan Yuan Li, and Benjamin Moeller. “Exploring the role of HIF-1 in early angiogenesis and response to radiotherapy.Radiother Oncol 83, no. 3 (June 2007): 249–55. https://doi.org/10.1016/j.radonc.2007.05.016.
Dewhirst MW, Cao Y, Li CY, Moeller B. Exploring the role of HIF-1 in early angiogenesis and response to radiotherapy. Radiother Oncol. 2007 Jun;83(3):249–55.
Dewhirst, Mark W., et al. “Exploring the role of HIF-1 in early angiogenesis and response to radiotherapy.Radiother Oncol, vol. 83, no. 3, June 2007, pp. 249–55. Pubmed, doi:10.1016/j.radonc.2007.05.016.
Dewhirst MW, Cao Y, Li CY, Moeller B. Exploring the role of HIF-1 in early angiogenesis and response to radiotherapy. Radiother Oncol. 2007 Jun;83(3):249–255.
Journal cover image

Published In

Radiother Oncol

DOI

ISSN

0167-8140

Publication Date

June 2007

Volume

83

Issue

3

Start / End Page

249 / 255

Location

Ireland

Related Subject Headings

  • Radiotherapy
  • Oncology & Carcinogenesis
  • Neovascularization, Pathologic
  • Hypoxia-Inducible Factor 1
  • Hypoxia
  • Humans
  • 5105 Medical and biological physics
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences
  • 1112 Oncology and Carcinogenesis