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Interstitial microwave-induced hyperthermia and iridium brachytherapy for the treatment of obstructing biliary carcinomas.

Publication ,  Journal Article
Coughlin, CT; Wong, TZ; Ryan, TP; Jones, EL; Crichlow, RW; Spiegel, PK; Jeffery, R
Published in: Int J Hyperthermia
1992

In a phase I clinical study, 10 patients with obstructive biliary carcinomas were treated with single-antenna interstitial microwave hyperthermia and iridium-192 brachytherapy. For each patient a standard biliary drainage catheter was implanted percutaneously through the obstructed common bile duct. This catheter accommodated a single microwave antenna which operated at 915 MHz, and one or two fibreoptic thermometry probes for temperature measurement. Under fluoroscopic guidance the microwave antenna and temperature probes were positioned in the CT-determined tumour mass. The 60-min heat treatment achieved a central tumour temperature of 45-55 degrees C while keeping temperatures at the proximal and distal margins at 43 degrees C. Immediately following the hyperthermia treatment the microwave antenna and temperature probes were removed, and a single strand of iridium-192 double-strength seeds was inserted to irradiate the tumour length. A dose of 5500-7900 cGy calculated at 0.5 cm radially from the catheter was administered over 5-7 days. Upon removal of the iridium a second hyperthermia treatment was performed. A total of 18 hyperthermia treatments were administered to the 10 patients. In two cases the second hyperthermia treatment after brachytherapy was not possible due to a kink in the catheter, or bile precipitation in the catheter. All patients tolerated the procedure well, and there were no acute complications. To evaluate the volumetric heating potential of this hyperthermia method, specific absorption rate (SAR) values were measured at 182 planar points in muscle phantom. Insulated and non-insulated antenna performance was tested at 915 MHz in a biliary catheter filled with air, saline, or bile to mimic clinical treatments. The insulated antenna exhibited the best performance. Differences between antenna performance in saline and bile were also noted. In summary, this technique may have potential for tumours which obstruct biliary drainage and are accessible to percutaneous decompression using standard diagnostic radiological procedures.

Duke Scholars

Published In

Int J Hyperthermia

DOI

ISSN

0265-6736

Publication Date

1992

Volume

8

Issue

2

Start / End Page

157 / 171

Location

England

Related Subject Headings

  • Temperature
  • Oncology & Carcinogenesis
  • Models, Structural
  • Microwaves
  • Iridium Radioisotopes
  • Hyperthermia, Induced
  • Humans
  • Combined Modality Therapy
  • Cholestasis, Extrahepatic
  • Brachytherapy
 

Citation

APA
Chicago
ICMJE
MLA
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Coughlin, C. T., Wong, T. Z., Ryan, T. P., Jones, E. L., Crichlow, R. W., Spiegel, P. K., & Jeffery, R. (1992). Interstitial microwave-induced hyperthermia and iridium brachytherapy for the treatment of obstructing biliary carcinomas. Int J Hyperthermia, 8(2), 157–171. https://doi.org/10.3109/02656739209021772
Coughlin, C. T., T. Z. Wong, T. P. Ryan, E. L. Jones, R. W. Crichlow, P. K. Spiegel, and R. Jeffery. “Interstitial microwave-induced hyperthermia and iridium brachytherapy for the treatment of obstructing biliary carcinomas.Int J Hyperthermia 8, no. 2 (1992): 157–71. https://doi.org/10.3109/02656739209021772.
Coughlin CT, Wong TZ, Ryan TP, Jones EL, Crichlow RW, Spiegel PK, et al. Interstitial microwave-induced hyperthermia and iridium brachytherapy for the treatment of obstructing biliary carcinomas. Int J Hyperthermia. 1992;8(2):157–71.
Coughlin, C. T., et al. “Interstitial microwave-induced hyperthermia and iridium brachytherapy for the treatment of obstructing biliary carcinomas.Int J Hyperthermia, vol. 8, no. 2, 1992, pp. 157–71. Pubmed, doi:10.3109/02656739209021772.
Coughlin CT, Wong TZ, Ryan TP, Jones EL, Crichlow RW, Spiegel PK, Jeffery R. Interstitial microwave-induced hyperthermia and iridium brachytherapy for the treatment of obstructing biliary carcinomas. Int J Hyperthermia. 1992;8(2):157–171.
Journal cover image

Published In

Int J Hyperthermia

DOI

ISSN

0265-6736

Publication Date

1992

Volume

8

Issue

2

Start / End Page

157 / 171

Location

England

Related Subject Headings

  • Temperature
  • Oncology & Carcinogenesis
  • Models, Structural
  • Microwaves
  • Iridium Radioisotopes
  • Hyperthermia, Induced
  • Humans
  • Combined Modality Therapy
  • Cholestasis, Extrahepatic
  • Brachytherapy