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Radiologic manifestations of sclerosing cholangitis with emphasis on MR cholangiopancreatography.

Publication ,  Journal Article
Vitellas, KM; Keogan, MT; Freed, KS; Enns, RA; Spritzer, CE; Baillie, JM; Nelson, RC
Published in: Radiographics
2000

Magnetic resonance cholangiopancreatography (MRCP) is a relatively new, noninvasive cholangiographic technique that is comparable with invasive endoscopic retrograde cholangiopancreatography (ERCP) in the detection and characterization of extrahepatic bile duct abnormalities. The role of MRCP in evaluation of the intrahepatic bile ducts, especially in patients with primary or secondary sclerosing cholangitis, is under investigation. The key cholangiographic features of primary sclerosing cholangitis are randomly distributed annular strictures out of proportion to upstream dilatation. As the fibrosing process worsens, strictures increase and the ducts become obliterated, and the peripheral ducts cannot be visualized to the periphery of the liver at ERCP. In addition, the acute angles formed with the central ducts become more obtuse. With further progression, strictures of the central ducts prevent peripheral ductal opacification at ERCP. Cholangiocarcinoma occurs in 10%-15% of patients with primary sclerosing cholangitis; cholangiographic features that suggest cholangiocarcinoma include irregular high-grade ductal narrowing with shouldered margins, rapid progression of strictures, marked ductal dilatation proximal to strictures, and polypoid lesions. Secondary sclerosing and nonsclerosing processes can mimic primary sclerosing cholangitis at cholangiography. These processes include ascending cholangitis, oriental cholangiohepatitis, acquired immunodeficiency syndrome-related cholangitis, chemotherapy-induced cholangitis, ischemic cholangitis after liver transplantation, eosinophilic cholangitis, and metastases.

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Published In

Radiographics

DOI

ISSN

0271-5333

Publication Date

2000

Volume

20

Issue

4

Start / End Page

959 / 975

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Imaging
  • Humans
  • Disease Progression
  • Dilatation, Pathologic
  • Diagnosis, Differential
  • Constriction, Pathologic
  • Cholangitis, Sclerosing
  • Cholangitis
  • Cholangiopancreatography, Endoscopic Retrograde
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Vitellas, K. M., Keogan, M. T., Freed, K. S., Enns, R. A., Spritzer, C. E., Baillie, J. M., & Nelson, R. C. (2000). Radiologic manifestations of sclerosing cholangitis with emphasis on MR cholangiopancreatography. Radiographics, 20(4), 959–975. https://doi.org/10.1148/radiographics.20.4.g00jl04959
Vitellas, K. M., M. T. Keogan, K. S. Freed, R. A. Enns, C. E. Spritzer, J. M. Baillie, and R. C. Nelson. “Radiologic manifestations of sclerosing cholangitis with emphasis on MR cholangiopancreatography.Radiographics 20, no. 4 (2000): 959–75. https://doi.org/10.1148/radiographics.20.4.g00jl04959.
Vitellas KM, Keogan MT, Freed KS, Enns RA, Spritzer CE, Baillie JM, et al. Radiologic manifestations of sclerosing cholangitis with emphasis on MR cholangiopancreatography. Radiographics. 2000;20(4):959–75.
Vitellas, K. M., et al. “Radiologic manifestations of sclerosing cholangitis with emphasis on MR cholangiopancreatography.Radiographics, vol. 20, no. 4, 2000, pp. 959–75. Pubmed, doi:10.1148/radiographics.20.4.g00jl04959.
Vitellas KM, Keogan MT, Freed KS, Enns RA, Spritzer CE, Baillie JM, Nelson RC. Radiologic manifestations of sclerosing cholangitis with emphasis on MR cholangiopancreatography. Radiographics. 2000;20(4):959–975.
Journal cover image

Published In

Radiographics

DOI

ISSN

0271-5333

Publication Date

2000

Volume

20

Issue

4

Start / End Page

959 / 975

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Imaging
  • Humans
  • Disease Progression
  • Dilatation, Pathologic
  • Diagnosis, Differential
  • Constriction, Pathologic
  • Cholangitis, Sclerosing
  • Cholangitis
  • Cholangiopancreatography, Endoscopic Retrograde