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The impact of postoperative atrial fibrillation on neurocognitive outcome after coronary artery bypass graft surgery.

Publication ,  Journal Article
Stanley, TO; Mackensen, GB; Grocott, HP; White, WD; Blumenthal, JA; Laskowitz, DT; Landolfo, KP; Reves, JG; Mathew, JP; Newman, MF ...
Published in: Anesth Analg
February 2002

UNLABELLED: Neurocognitive decline is a continuing source of morbidity after cardiac surgery. Atrial fibrillation occurs often after cardiac surgery and has been linked to adverse neurologic events. We sought to determine whether postoperative atrial fibrillation was associated with postoperative cognitive dysfunction. Four-hundred-eleven patients were enrolled to receive a battery of neurocognitive tests both preoperatively and 6 wk after elective coronary artery bypass graft surgery. Neurocognitive test scores were separated into four cognitive domains, with a composite cognitive index (the mean of the four domain scores) determined for each patient at every testing period. Multivariable analysis controlling for age, years of education, diabetes mellitus, left ventricular ejection fraction, and preoperative atrial fibrillation compared the presence of postoperative atrial fibrillation with change in cognitive function. Three-hundred-eight patients completed both pre- and postoperative cognitive testing; 69 patients (22%) had postoperative atrial fibrillation. Those who developed atrial fibrillation showed more cognitive decline than those who did not develop postoperative atrial fibrillation (P = 0.036). Atrial fibrillation was associated with poorer cognitive function 6 wk after surgery. Although the mechanism of this association is yet to be determined, prevention of atrial fibrillation may result in improved neurocognitive function. IMPLICATIONS: Neurocognitive dysfunction is common after coronary artery bypass graft surgery. The relationship between atrial fibrillation and neurocognitive dysfunction has not been examined. Our study shows that postoperative atrial fibrillation is associated with neurocognitive decline.

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Published In

Anesth Analg

DOI

ISSN

0003-2999

Publication Date

February 2002

Volume

94

Issue

2

Start / End Page

290 / 295

Location

United States

Related Subject Headings

  • Risk Factors
  • Psychological Tests
  • Prospective Studies
  • Middle Aged
  • Male
  • Humans
  • Female
  • Coronary Artery Bypass
  • Cognition Disorders
  • Atrial Fibrillation
 

Citation

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Stanley, T. O., Mackensen, G. B., Grocott, H. P., White, W. D., Blumenthal, J. A., Laskowitz, D. T., … CARE Investigators of the Duke Heart Center, . (2002). The impact of postoperative atrial fibrillation on neurocognitive outcome after coronary artery bypass graft surgery. Anesth Analg, 94(2), 290–295. https://doi.org/10.1097/00000539-200202000-00011
Stanley, Timothy O., G Burkhard Mackensen, Hilary P. Grocott, William D. White, James A. Blumenthal, Daniel T. Laskowitz, Kevin P. Landolfo, et al. “The impact of postoperative atrial fibrillation on neurocognitive outcome after coronary artery bypass graft surgery.Anesth Analg 94, no. 2 (February 2002): 290–95. https://doi.org/10.1097/00000539-200202000-00011.
Stanley TO, Mackensen GB, Grocott HP, White WD, Blumenthal JA, Laskowitz DT, et al. The impact of postoperative atrial fibrillation on neurocognitive outcome after coronary artery bypass graft surgery. Anesth Analg. 2002 Feb;94(2):290–5.
Stanley, Timothy O., et al. “The impact of postoperative atrial fibrillation on neurocognitive outcome after coronary artery bypass graft surgery.Anesth Analg, vol. 94, no. 2, Feb. 2002, pp. 290–95. Pubmed, doi:10.1097/00000539-200202000-00011.
Stanley TO, Mackensen GB, Grocott HP, White WD, Blumenthal JA, Laskowitz DT, Landolfo KP, Reves JG, Mathew JP, Newman MF, Neurological Outcome Research Group, CARE Investigators of the Duke Heart Center. The impact of postoperative atrial fibrillation on neurocognitive outcome after coronary artery bypass graft surgery. Anesth Analg. 2002 Feb;94(2):290–295.

Published In

Anesth Analg

DOI

ISSN

0003-2999

Publication Date

February 2002

Volume

94

Issue

2

Start / End Page

290 / 295

Location

United States

Related Subject Headings

  • Risk Factors
  • Psychological Tests
  • Prospective Studies
  • Middle Aged
  • Male
  • Humans
  • Female
  • Coronary Artery Bypass
  • Cognition Disorders
  • Atrial Fibrillation