Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response.
Publication
, Journal Article
Lynch, JR; Morgan, D; Mance, J; Matthew, WD; Laskowitz, DT
Published in: J Neuroimmunol
March 1, 2001
Apolipoprotein E (apoE) is a 299 amino acid protein that is associated with risk of developing Alzheimer's Disease (AD) and outcome after acute brain injury. To investigate the possibility that apoE modulates glial activation we studied the effect of endogenous apoE on inflammatory gene regulation in vitro and in vivo. Our results indicate that apoE downregulates CNS production of TNFalpha, Il-1beta, and Il-6 mRNA following stimulation with lipopolysaccharide (LPS). This effect of endogenous apoE on inflammatory gene regulation appears to be specific, and may account for the biological role that apoE plays in acute and chronic human neurological disease.
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Published In
J Neuroimmunol
DOI
ISSN
0165-5728
Publication Date
March 1, 2001
Volume
114
Issue
1-2
Start / End Page
107 / 113
Location
Netherlands
Related Subject Headings
- Tumor Necrosis Factor-alpha
- RNA, Messenger
- Neurology & Neurosurgery
- Microglia
- Mice, Mutant Strains
- Mice, Inbred C57BL
- Mice
- Male
- Lipopolysaccharides
- Interleukin-6
Citation
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Lynch, J. R., Morgan, D., Mance, J., Matthew, W. D., & Laskowitz, D. T. (2001). Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response. J Neuroimmunol, 114(1–2), 107–113. https://doi.org/10.1016/s0165-5728(00)00459-8
Lynch, J. R., D. Morgan, J. Mance, W. D. Matthew, and D. T. Laskowitz. “Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response.” J Neuroimmunol 114, no. 1–2 (March 1, 2001): 107–13. https://doi.org/10.1016/s0165-5728(00)00459-8.
Lynch JR, Morgan D, Mance J, Matthew WD, Laskowitz DT. Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response. J Neuroimmunol. 2001 Mar 1;114(1–2):107–13.
Lynch, J. R., et al. “Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response.” J Neuroimmunol, vol. 114, no. 1–2, Mar. 2001, pp. 107–13. Pubmed, doi:10.1016/s0165-5728(00)00459-8.
Lynch JR, Morgan D, Mance J, Matthew WD, Laskowitz DT. Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response. J Neuroimmunol. 2001 Mar 1;114(1–2):107–113.
Published In
J Neuroimmunol
DOI
ISSN
0165-5728
Publication Date
March 1, 2001
Volume
114
Issue
1-2
Start / End Page
107 / 113
Location
Netherlands
Related Subject Headings
- Tumor Necrosis Factor-alpha
- RNA, Messenger
- Neurology & Neurosurgery
- Microglia
- Mice, Mutant Strains
- Mice, Inbred C57BL
- Mice
- Male
- Lipopolysaccharides
- Interleukin-6