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Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response.

Publication ,  Journal Article
Lynch, JR; Morgan, D; Mance, J; Matthew, WD; Laskowitz, DT
Published in: J Neuroimmunol
March 1, 2001

Apolipoprotein E (apoE) is a 299 amino acid protein that is associated with risk of developing Alzheimer's Disease (AD) and outcome after acute brain injury. To investigate the possibility that apoE modulates glial activation we studied the effect of endogenous apoE on inflammatory gene regulation in vitro and in vivo. Our results indicate that apoE downregulates CNS production of TNFalpha, Il-1beta, and Il-6 mRNA following stimulation with lipopolysaccharide (LPS). This effect of endogenous apoE on inflammatory gene regulation appears to be specific, and may account for the biological role that apoE plays in acute and chronic human neurological disease.

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Published In

J Neuroimmunol

DOI

ISSN

0165-5728

Publication Date

March 1, 2001

Volume

114

Issue

1-2

Start / End Page

107 / 113

Location

Netherlands

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • RNA, Messenger
  • Neurology & Neurosurgery
  • Microglia
  • Mice, Mutant Strains
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Lipopolysaccharides
  • Interleukin-6
 

Citation

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Lynch, J. R., Morgan, D., Mance, J., Matthew, W. D., & Laskowitz, D. T. (2001). Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response. J Neuroimmunol, 114(1–2), 107–113. https://doi.org/10.1016/s0165-5728(00)00459-8
Lynch, J. R., D. Morgan, J. Mance, W. D. Matthew, and D. T. Laskowitz. “Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response.J Neuroimmunol 114, no. 1–2 (March 1, 2001): 107–13. https://doi.org/10.1016/s0165-5728(00)00459-8.
Lynch JR, Morgan D, Mance J, Matthew WD, Laskowitz DT. Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response. J Neuroimmunol. 2001 Mar 1;114(1–2):107–13.
Lynch, J. R., et al. “Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response.J Neuroimmunol, vol. 114, no. 1–2, Mar. 2001, pp. 107–13. Pubmed, doi:10.1016/s0165-5728(00)00459-8.
Lynch JR, Morgan D, Mance J, Matthew WD, Laskowitz DT. Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response. J Neuroimmunol. 2001 Mar 1;114(1–2):107–113.
Journal cover image

Published In

J Neuroimmunol

DOI

ISSN

0165-5728

Publication Date

March 1, 2001

Volume

114

Issue

1-2

Start / End Page

107 / 113

Location

Netherlands

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • RNA, Messenger
  • Neurology & Neurosurgery
  • Microglia
  • Mice, Mutant Strains
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Lipopolysaccharides
  • Interleukin-6