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Genome-wide association analysis of rheumatoid arthritis data via haplotype sharing.

Publication ,  Journal Article
Allen, AS; Satten, GA
Published in: BMC Proc
December 15, 2009

We present computationally simple association tests based on haplotype sharing that can be easily applied to genome-wide association studies, while allowing use of fast (but not likelihood-based) haplotyping algorithms, and properly accounting for the uncertainty introduced by using inferred haplotypes. We also give haplotype sharing analyses that adjust for population stratification. We apply our methods to a genome-wide association study of rheumatoid arthritis available as Problem 1 of Genetic Analysis Workshop 16. In addition to the HLA region on chromosome 6, we find genome-wide significant signals at 7q33 and 13q31.3. These regions contain genes with interesting potential connections with rheumatoid arthritis and are not identified using single single-nucleotide polymorphism methods.

Duke Scholars

Published In

BMC Proc

DOI

EISSN

1753-6561

Publication Date

December 15, 2009

Volume

3 Suppl 7

Issue

Suppl 7

Start / End Page

S30

Location

England
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Allen, A. S., & Satten, G. A. (2009). Genome-wide association analysis of rheumatoid arthritis data via haplotype sharing. BMC Proc, 3 Suppl 7(Suppl 7), S30. https://doi.org/10.1186/1753-6561-3-s7-s30
Allen, Andrew S., and Glen A. Satten. “Genome-wide association analysis of rheumatoid arthritis data via haplotype sharing.BMC Proc 3 Suppl 7, no. Suppl 7 (December 15, 2009): S30. https://doi.org/10.1186/1753-6561-3-s7-s30.
Allen AS, Satten GA. Genome-wide association analysis of rheumatoid arthritis data via haplotype sharing. BMC Proc. 2009 Dec 15;3 Suppl 7(Suppl 7):S30.
Allen, Andrew S., and Glen A. Satten. “Genome-wide association analysis of rheumatoid arthritis data via haplotype sharing.BMC Proc, vol. 3 Suppl 7, no. Suppl 7, Dec. 2009, p. S30. Pubmed, doi:10.1186/1753-6561-3-s7-s30.
Allen AS, Satten GA. Genome-wide association analysis of rheumatoid arthritis data via haplotype sharing. BMC Proc. 2009 Dec 15;3 Suppl 7(Suppl 7):S30.
Journal cover image

Published In

BMC Proc

DOI

EISSN

1753-6561

Publication Date

December 15, 2009

Volume

3 Suppl 7

Issue

Suppl 7

Start / End Page

S30

Location

England