Protein S deficiency: imaging findings.
Protein S deficiency is an autosomal-dominant inherited disorder of coagulation associated with spontaneous and recurrent venous thrombosis. Approximately 5% of patients with deep venous thrombosis of the lower extremities who are less than 45 years old have a deficiency of protein S. Patients frequently have spontaneous and recurrent deep venous thrombosis and pulmonary embolism during young adulthood. Thrombosis occurs less commonly in the splanchnic and cerebral veins. Arterial thrombosis is rare but is seen in the cerebral circulation. Radiologists should include protein S deficiency in the differential diagnosis of unexplained thrombosis in young patients. This pictorial essay illustrates the range of imaging findings encountered in patients with this disorder.
Duke Scholars
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Related Subject Headings
- Thrombosis
- Protein S Deficiency
- Nuclear Medicine & Medical Imaging
- Male
- Humans
- Female
- Diagnostic Imaging
- Diagnosis, Differential
- Adult
- 3202 Clinical sciences
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Thrombosis
- Protein S Deficiency
- Nuclear Medicine & Medical Imaging
- Male
- Humans
- Female
- Diagnostic Imaging
- Diagnosis, Differential
- Adult
- 3202 Clinical sciences