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The role of apolipoprotein E in Alzheimer's disease: pharmacogenomic target selection.

Publication ,  Journal Article
Saunders, AM; Trowers, MK; Shimkets, RA; Blakemore, S; Crowther, DJ; Mansfield, TA; Wallace, DM; Strittmatter, WJ; Roses, AD
Published in: Biochim Biophys Acta
July 26, 2000

The association of inheritance of different apolipoprotein E (APOE, gene; apoE, protein) alleles with the risk and rate of onset of Alzheimer's disease (AD) is now well established and widely confirmed. While there are now a collection of hypotheses concerning the specific relationship of APOE polymorphisms to various phenotypic manifestations of AD, no single compelling theory has been tested and universally accepted. The only clear fact emerging during the past 6 years is that differences in APOE genotype affect the average rate of disease onset as a predictable function of the inheritance of this polymorphic gene. Methods now exist to enable experimental designs to study the metabolic effects of inheriting different APOE alleles, addressing what differences that may be present for many years, perhaps over the entire lifetime, can lead to earlier or later manifestations of the disease and are therapeutically tractable. This review summarizes part of an experimental approach to identify biological pathways influenced by the different APOE polymorphisms that are relevant to the pathogenesis of AD.

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Published In

Biochim Biophys Acta

DOI

ISSN

0006-3002

Publication Date

July 26, 2000

Volume

1502

Issue

1

Start / End Page

85 / 94

Location

Netherlands

Related Subject Headings

  • RNA, Messenger
  • Polymorphism, Genetic
  • Humans
  • Genotype
  • Genetic Techniques
  • Gene Targeting
  • Gene Expression Regulation
  • Disease Models, Animal
  • Brain
  • Apolipoproteins E
 

Citation

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ICMJE
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Saunders, A. M., Trowers, M. K., Shimkets, R. A., Blakemore, S., Crowther, D. J., Mansfield, T. A., … Roses, A. D. (2000). The role of apolipoprotein E in Alzheimer's disease: pharmacogenomic target selection. Biochim Biophys Acta, 1502(1), 85–94. https://doi.org/10.1016/s0925-4439(00)00035-1
Saunders, A. M., M. K. Trowers, R. A. Shimkets, S. Blakemore, D. J. Crowther, T. A. Mansfield, D. M. Wallace, W. J. Strittmatter, and A. D. Roses. “The role of apolipoprotein E in Alzheimer's disease: pharmacogenomic target selection.Biochim Biophys Acta 1502, no. 1 (July 26, 2000): 85–94. https://doi.org/10.1016/s0925-4439(00)00035-1.
Saunders AM, Trowers MK, Shimkets RA, Blakemore S, Crowther DJ, Mansfield TA, et al. The role of apolipoprotein E in Alzheimer's disease: pharmacogenomic target selection. Biochim Biophys Acta. 2000 Jul 26;1502(1):85–94.
Saunders, A. M., et al. “The role of apolipoprotein E in Alzheimer's disease: pharmacogenomic target selection.Biochim Biophys Acta, vol. 1502, no. 1, July 2000, pp. 85–94. Pubmed, doi:10.1016/s0925-4439(00)00035-1.
Saunders AM, Trowers MK, Shimkets RA, Blakemore S, Crowther DJ, Mansfield TA, Wallace DM, Strittmatter WJ, Roses AD. The role of apolipoprotein E in Alzheimer's disease: pharmacogenomic target selection. Biochim Biophys Acta. 2000 Jul 26;1502(1):85–94.

Published In

Biochim Biophys Acta

DOI

ISSN

0006-3002

Publication Date

July 26, 2000

Volume

1502

Issue

1

Start / End Page

85 / 94

Location

Netherlands

Related Subject Headings

  • RNA, Messenger
  • Polymorphism, Genetic
  • Humans
  • Genotype
  • Genetic Techniques
  • Gene Targeting
  • Gene Expression Regulation
  • Disease Models, Animal
  • Brain
  • Apolipoproteins E