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A molecular genetic study of intracerebral hemorrhage.

Publication ,  Journal Article
Graffagnino, C; Herbstreith, MH; Roses, AD; Alberts, MJ
Published in: Arch Neurol
October 1994

BACKGROUND: Two forms of inherited intracerebral hemorrhage (ICH) are associated with an amyloid angiopathy caused by mutations in the genes for the amyloid precursor protein or cystatin C. The purpose of this study was to determine whether patients with sporadic ICH have mutations in the amyloid precursor protein or cystatin C genes. METHODS: Consecutive patients with ICH admitted to the neurology or neurosurgery services at Duke University Hospital, Durham, NC, were studied. Using the polymerase chain reaction, we amplified exons 16 and 17 of the amyloid precursor protein and exon 2 of cystatin C and sequenced the products. Twenty-six men and 22 women were studied. The ICH location was deep in 29 patients, lobar in 16, cerebellar in two, and brain stem in one. There were 30 patients (63%) with a positive family history of stroke; seven of them (15%) had a family history of ICH. CONCLUSIONS: Mutations previously reported to cause familial forms of ICH were not found in this group of patients.

Duke Scholars

Published In

Arch Neurol

DOI

ISSN

0003-9942

Publication Date

October 1994

Volume

51

Issue

10

Start / End Page

981 / 984

Location

United States

Related Subject Headings

  • Neurology & Neurosurgery
  • Mutation
  • Molecular Sequence Data
  • Middle Aged
  • Male
  • Humans
  • Female
  • Cystatins
  • Cystatin C
  • Cerebral Hemorrhage
 

Citation

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Graffagnino, C., Herbstreith, M. H., Roses, A. D., & Alberts, M. J. (1994). A molecular genetic study of intracerebral hemorrhage. Arch Neurol, 51(10), 981–984. https://doi.org/10.1001/archneur.1994.00540220027011
Graffagnino, C., M. H. Herbstreith, A. D. Roses, and M. J. Alberts. “A molecular genetic study of intracerebral hemorrhage.Arch Neurol 51, no. 10 (October 1994): 981–84. https://doi.org/10.1001/archneur.1994.00540220027011.
Graffagnino C, Herbstreith MH, Roses AD, Alberts MJ. A molecular genetic study of intracerebral hemorrhage. Arch Neurol. 1994 Oct;51(10):981–4.
Graffagnino, C., et al. “A molecular genetic study of intracerebral hemorrhage.Arch Neurol, vol. 51, no. 10, Oct. 1994, pp. 981–84. Pubmed, doi:10.1001/archneur.1994.00540220027011.
Graffagnino C, Herbstreith MH, Roses AD, Alberts MJ. A molecular genetic study of intracerebral hemorrhage. Arch Neurol. 1994 Oct;51(10):981–984.

Published In

Arch Neurol

DOI

ISSN

0003-9942

Publication Date

October 1994

Volume

51

Issue

10

Start / End Page

981 / 984

Location

United States

Related Subject Headings

  • Neurology & Neurosurgery
  • Mutation
  • Molecular Sequence Data
  • Middle Aged
  • Male
  • Humans
  • Female
  • Cystatins
  • Cystatin C
  • Cerebral Hemorrhage