The Q7R Saitohin gene polymorphism is not associated with Alzheimer disease.
Publication
, Journal Article
Oliveira, SA; Martin, ER; Scott, WK; Nicodemus, KK; Small, GW; Schmechel, DE; Doraiswamy, PM; Roses, AD; Saunders, AM; Gilbert, JR; Haines, JL ...
Published in: Neurosci Lett
August 28, 2003
Previous studies have reported conflicting results regarding the association of the Q7R polymorphism in the Saitohin gene with late-onset Alzheimer disease (AD). Given that AD is a tauopathy but no mutations or polymorphisms in Tau have been consistently associated with AD, and that Saitohin is nested in intron 9 of Tau and shares a similar expression pattern, we tested this association in 690 multiplex AD families and in a case-control sample (903 patients and 320 controls). We found no evidence of significant association of this polymorphism with risk of AD using family-based and case-control tests of association.
Duke Scholars
Published In
Neurosci Lett
DOI
ISSN
0304-3940
Publication Date
August 28, 2003
Volume
347
Issue
3
Start / End Page
143 / 146
Location
Ireland
Related Subject Headings
- tau Proteins
- Polymorphism, Genetic
- Humans
- Genotype
- Genetic Predisposition to Disease
- Case-Control Studies
- Alzheimer Disease
- 5202 Biological psychology
- 3209 Neurosciences
- 3101 Biochemistry and cell biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Oliveira, S. A., Martin, E. R., Scott, W. K., Nicodemus, K. K., Small, G. W., Schmechel, D. E., … Pericak-Vance, M. A. (2003). The Q7R Saitohin gene polymorphism is not associated with Alzheimer disease. Neurosci Lett, 347(3), 143–146. https://doi.org/10.1016/s0304-3940(03)00670-0
Oliveira, Sofia A., Eden R. Martin, William K. Scott, Kristin K. Nicodemus, Gary W. Small, Donald E. Schmechel, P Murali Doraiswamy, et al. “The Q7R Saitohin gene polymorphism is not associated with Alzheimer disease.” Neurosci Lett 347, no. 3 (August 28, 2003): 143–46. https://doi.org/10.1016/s0304-3940(03)00670-0.
Oliveira SA, Martin ER, Scott WK, Nicodemus KK, Small GW, Schmechel DE, et al. The Q7R Saitohin gene polymorphism is not associated with Alzheimer disease. Neurosci Lett. 2003 Aug 28;347(3):143–6.
Oliveira, Sofia A., et al. “The Q7R Saitohin gene polymorphism is not associated with Alzheimer disease.” Neurosci Lett, vol. 347, no. 3, Aug. 2003, pp. 143–46. Pubmed, doi:10.1016/s0304-3940(03)00670-0.
Oliveira SA, Martin ER, Scott WK, Nicodemus KK, Small GW, Schmechel DE, Doraiswamy PM, Roses AD, Saunders AM, Gilbert JR, Haines JL, Vance JM, Pericak-Vance MA. The Q7R Saitohin gene polymorphism is not associated with Alzheimer disease. Neurosci Lett. 2003 Aug 28;347(3):143–146.
Published In
Neurosci Lett
DOI
ISSN
0304-3940
Publication Date
August 28, 2003
Volume
347
Issue
3
Start / End Page
143 / 146
Location
Ireland
Related Subject Headings
- tau Proteins
- Polymorphism, Genetic
- Humans
- Genotype
- Genetic Predisposition to Disease
- Case-Control Studies
- Alzheimer Disease
- 5202 Biological psychology
- 3209 Neurosciences
- 3101 Biochemistry and cell biology