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Sequestration of amyloid beta-peptide.

Publication ,  Journal Article
Goldgaber, D; Schwarzman, AI; Bhasin, R; Gregori, L; Schmechel, D; Saunders, AM; Roses, AD; Strittmatter, WJ
Published in: Ann N Y Acad Sci
September 24, 1993

Amyloid beta-protein, or beta/A4, is a 4-kilodalton peptide that forms poorly soluble extracellular depositions of amyloid in brains and leptomeninges of patients with Alzheimer's disease (AD), Down's syndrome (DS), and hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D). beta/A4 peptide is a derivative of a large transmembrane glycoprotein (APP) and is found in the extracellular space, i.e., in the cerebrospinal fluid and serum of individuals with and without AD and in the conditioned media of many different cells grown in culture. The mechanism by which normally produced amyloid beta peptide forms extracellular aggregates in patients is unknown. One possible explanation is a failure of a mechanism for removal of the beta/A4 peptide that prevents this highly aggregating peptide from forming extracellular amyloid depositions.

Duke Scholars

Published In

Ann N Y Acad Sci

DOI

ISSN

0077-8923

Publication Date

September 24, 1993

Volume

695

Start / End Page

139 / 143

Location

United States

Related Subject Headings

  • Protein Binding
  • Humans
  • General Science & Technology
  • Down Syndrome
  • Culture Media, Conditioned
  • Cerebral Hemorrhage
  • Cells, Cultured
  • Brain
  • Apolipoproteins E
  • Amyloidosis
 

Citation

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Goldgaber, D., Schwarzman, A. I., Bhasin, R., Gregori, L., Schmechel, D., Saunders, A. M., … Strittmatter, W. J. (1993). Sequestration of amyloid beta-peptide. Ann N Y Acad Sci, 695, 139–143. https://doi.org/10.1111/j.1749-6632.1993.tb23042.x
Goldgaber, D., A. I. Schwarzman, R. Bhasin, L. Gregori, D. Schmechel, A. M. Saunders, A. D. Roses, and W. J. Strittmatter. “Sequestration of amyloid beta-peptide.Ann N Y Acad Sci 695 (September 24, 1993): 139–43. https://doi.org/10.1111/j.1749-6632.1993.tb23042.x.
Goldgaber D, Schwarzman AI, Bhasin R, Gregori L, Schmechel D, Saunders AM, et al. Sequestration of amyloid beta-peptide. Ann N Y Acad Sci. 1993 Sep 24;695:139–43.
Goldgaber, D., et al. “Sequestration of amyloid beta-peptide.Ann N Y Acad Sci, vol. 695, Sept. 1993, pp. 139–43. Pubmed, doi:10.1111/j.1749-6632.1993.tb23042.x.
Goldgaber D, Schwarzman AI, Bhasin R, Gregori L, Schmechel D, Saunders AM, Roses AD, Strittmatter WJ. Sequestration of amyloid beta-peptide. Ann N Y Acad Sci. 1993 Sep 24;695:139–143.
Journal cover image

Published In

Ann N Y Acad Sci

DOI

ISSN

0077-8923

Publication Date

September 24, 1993

Volume

695

Start / End Page

139 / 143

Location

United States

Related Subject Headings

  • Protein Binding
  • Humans
  • General Science & Technology
  • Down Syndrome
  • Culture Media, Conditioned
  • Cerebral Hemorrhage
  • Cells, Cultured
  • Brain
  • Apolipoproteins E
  • Amyloidosis