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Differences in brain volumes among males and female hormone-therapy users and nonusers.

Publication ,  Journal Article
Greenberg, DL; Payne, ME; MacFall, JR; Provenzale, JM; Steffens, DC; Krishnan, RR
Published in: Psychiatry Res
October 30, 2006

Numerous studies have shown gender differences in the brain volumes of elderly adults. Some evidence shows that higher estrogen levels may be neuroprotective, suggesting that hormone therapy (HT) may in part be responsible for these gender differences; however, few studies have examined the relation between HT and brain volumes. Brain volumes of caudate, putamen, hippocampus, gray matter, white matter, white-matter lesions, and cerebrospinal fluid were measured on magnetic resonance imaging scans. A comprehensive neuropsychological battery was administered. Women were separated into two groups based on HT use, and we used multiple regression analyses to compare these groups with one another and with men. Results of brain-volume measurements showed that HT users had significantly less gray matter and more cerebrospinal fluid than nonusers. Results of the neuropsychological testing showed that HT users performed better on the Shipley Vocabulary Test than males did.

Duke Scholars

Published In

Psychiatry Res

DOI

ISSN

0165-1781

Publication Date

October 30, 2006

Volume

147

Issue

2-3

Start / End Page

127 / 134

Location

Ireland

Related Subject Headings

  • Psychiatry
  • Neuropsychological Tests
  • Medroxyprogesterone Acetate
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Health Status
  • Female
  • Estrone
  • Estrogens, Conjugated (USP)
 

Citation

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Greenberg, D. L., Payne, M. E., MacFall, J. R., Provenzale, J. M., Steffens, D. C., & Krishnan, R. R. (2006). Differences in brain volumes among males and female hormone-therapy users and nonusers. Psychiatry Res, 147(2–3), 127–134. https://doi.org/10.1016/j.pscychresns.2006.01.001
Greenberg, Daniel L., Martha E. Payne, James R. MacFall, James M. Provenzale, David C. Steffens, and Ranga R. Krishnan. “Differences in brain volumes among males and female hormone-therapy users and nonusers.Psychiatry Res 147, no. 2–3 (October 30, 2006): 127–34. https://doi.org/10.1016/j.pscychresns.2006.01.001.
Greenberg DL, Payne ME, MacFall JR, Provenzale JM, Steffens DC, Krishnan RR. Differences in brain volumes among males and female hormone-therapy users and nonusers. Psychiatry Res. 2006 Oct 30;147(2–3):127–34.
Greenberg, Daniel L., et al. “Differences in brain volumes among males and female hormone-therapy users and nonusers.Psychiatry Res, vol. 147, no. 2–3, Oct. 2006, pp. 127–34. Pubmed, doi:10.1016/j.pscychresns.2006.01.001.
Greenberg DL, Payne ME, MacFall JR, Provenzale JM, Steffens DC, Krishnan RR. Differences in brain volumes among males and female hormone-therapy users and nonusers. Psychiatry Res. 2006 Oct 30;147(2–3):127–134.
Journal cover image

Published In

Psychiatry Res

DOI

ISSN

0165-1781

Publication Date

October 30, 2006

Volume

147

Issue

2-3

Start / End Page

127 / 134

Location

Ireland

Related Subject Headings

  • Psychiatry
  • Neuropsychological Tests
  • Medroxyprogesterone Acetate
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Health Status
  • Female
  • Estrone
  • Estrogens, Conjugated (USP)